Selective Estrogen Receptor Modulators Regulate Dendritic Spine Plasticity in the Hippocampus of Male Rats
Some selective estrogen receptor modulators, such as raloxifene and tamoxifen, are neuroprotective and reduce brain inflammation in several experimental models of neurodegeneration. In addition, raloxifene and tamoxifen counteract cognitive deficits caused by gonadal hormone deprivation in male rats...
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2012-01-01
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Series: | Neural Plasticity |
Online Access: | http://dx.doi.org/10.1155/2012/309494 |
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doaj-63458ade4c594174a930487c98cd329b2020-11-25T00:36:23ZengHindawi LimitedNeural Plasticity2090-59041687-54432012-01-01201210.1155/2012/309494309494Selective Estrogen Receptor Modulators Regulate Dendritic Spine Plasticity in the Hippocampus of Male RatsIgnacio González-Burgos0Martha C. Rivera-Cervantes1Dulce A. Velázquez-Zamora2Alfredo Feria-Velasco3Luis Miguel Garcia-Segura4Centro de Investigación Biomédica de Occidente, Guadalajara, Jalisco 44340, MexicoCUCBA, Universidad de Guadalajara, Guadalajara, Jalisco 45100, MexicoCentro de Investigación Biomédica de Occidente, Guadalajara, Jalisco 44340, MexicoCUCBA, Universidad de Guadalajara, Guadalajara, Jalisco 45100, MexicoInstituto Cajal, CSIC, 28002 Madrid, SpainSome selective estrogen receptor modulators, such as raloxifene and tamoxifen, are neuroprotective and reduce brain inflammation in several experimental models of neurodegeneration. In addition, raloxifene and tamoxifen counteract cognitive deficits caused by gonadal hormone deprivation in male rats. In this study, we have explored whether raloxifene and tamoxifen may regulate the number and geometry of dendritic spines in CA1 pyramidal neurons of the rat hippocampus. Young adult male rats were injected with raloxifene (1 mg/kg), tamoxifen (1 mg/kg), or vehicle and killed 24 h after the injection. Animals treated with raloxifene or tamoxifen showed an increased numerical density of dendritic spines in CA1 pyramidal neurons compared to animals treated with vehicle. Raloxifene and tamoxifen had also specific effects in the morphology of spines. These findings suggest that raloxifene and tamoxifen may influence the processing of information by hippocampal pyramidal neurons by affecting the number and shape of dendritic spines.http://dx.doi.org/10.1155/2012/309494 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ignacio González-Burgos Martha C. Rivera-Cervantes Dulce A. Velázquez-Zamora Alfredo Feria-Velasco Luis Miguel Garcia-Segura |
spellingShingle |
Ignacio González-Burgos Martha C. Rivera-Cervantes Dulce A. Velázquez-Zamora Alfredo Feria-Velasco Luis Miguel Garcia-Segura Selective Estrogen Receptor Modulators Regulate Dendritic Spine Plasticity in the Hippocampus of Male Rats Neural Plasticity |
author_facet |
Ignacio González-Burgos Martha C. Rivera-Cervantes Dulce A. Velázquez-Zamora Alfredo Feria-Velasco Luis Miguel Garcia-Segura |
author_sort |
Ignacio González-Burgos |
title |
Selective Estrogen Receptor Modulators Regulate Dendritic Spine Plasticity in the Hippocampus of Male Rats |
title_short |
Selective Estrogen Receptor Modulators Regulate Dendritic Spine Plasticity in the Hippocampus of Male Rats |
title_full |
Selective Estrogen Receptor Modulators Regulate Dendritic Spine Plasticity in the Hippocampus of Male Rats |
title_fullStr |
Selective Estrogen Receptor Modulators Regulate Dendritic Spine Plasticity in the Hippocampus of Male Rats |
title_full_unstemmed |
Selective Estrogen Receptor Modulators Regulate Dendritic Spine Plasticity in the Hippocampus of Male Rats |
title_sort |
selective estrogen receptor modulators regulate dendritic spine plasticity in the hippocampus of male rats |
publisher |
Hindawi Limited |
series |
Neural Plasticity |
issn |
2090-5904 1687-5443 |
publishDate |
2012-01-01 |
description |
Some selective estrogen receptor modulators, such as raloxifene and tamoxifen, are neuroprotective and reduce brain inflammation in several experimental models of neurodegeneration. In addition, raloxifene and tamoxifen counteract cognitive deficits caused by gonadal hormone deprivation in male rats. In this study, we have explored whether raloxifene and tamoxifen may regulate the number and geometry of dendritic spines in CA1 pyramidal neurons of the rat hippocampus. Young adult male rats were injected with raloxifene (1 mg/kg), tamoxifen (1 mg/kg), or vehicle and killed 24 h after the injection. Animals treated with raloxifene or tamoxifen showed an increased numerical density of dendritic spines in CA1 pyramidal neurons compared to animals treated with vehicle. Raloxifene and tamoxifen had also specific effects in the morphology of spines. These findings suggest that raloxifene and tamoxifen may influence the processing of information by hippocampal pyramidal neurons by affecting the number and shape of dendritic spines. |
url |
http://dx.doi.org/10.1155/2012/309494 |
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