Development of phosphonate-terminated magnetic mesoporous silica nanoparticles for pH-controlled release of doxorubicin and improved tumor accumulation

Development of phosphonate-terminated magnetic mesoporous silica nanoparticles for pH-controlled release of doxorubicin and improved tumor accumulation

In this study, phosphonate-terminated magnetic mesoporous nanoparticles (pMMSNs) was designed by incorporation of MNPs in the center of mesoporous silica nanoparticles (MSNs) and followed by grafting phosphonate group on to the surface of MMSNs. The carrier exhibited a typical superparamagnetic feat...

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Bibliographic Details
Main Authors: Erxi Che, Long Wan, Ying Zhang, Qinfu Zhao, Xiling Han, Jia Li, Jia Liu, Siling Wang
Format: Article
Language:English
Published: Elsevier 2014-12-01
Series:Asian Journal of Pharmaceutical Sciences
Subjects:
Magnetic mesoporous silica nanoparticles
Doxorubicin
pH-depended release
Tumor accumulation
Online Access:http://www.sciencedirect.com/science/article/pii/S1818087614000531

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