Hepatitis C virus infection among injection drug users with and without human immunodeficiency virus co-infection.
The aim of this study is to explore the prevalence of hepatitis C virus (HCV) infection among injection drug users (IDUs) with and without human immunodeficiency virus (HIV) infection in southern Taiwan. For 562 IDUs (265 anti-HIV negative, 297 anti-HIV positive), we analyzed liver function, anti-HI...
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doaj-634f7648fa6c47e6af8c91c19ca423ab2020-11-25T01:19:08ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0194e9479110.1371/journal.pone.0094791Hepatitis C virus infection among injection drug users with and without human immunodeficiency virus co-infection.Meng-Hsuan HsiehJih-Jin TsaiMing-Yen HsiehChung-Feng HuangMing-Lun YehJeng-Fu YangKo ChangWei-Ru LinChun-Yu LinTun-Chieh ChenJee-Fu HuangChia-Yen DaiMing-Lung YuWan-Long ChuangThe aim of this study is to explore the prevalence of hepatitis C virus (HCV) infection among injection drug users (IDUs) with and without human immunodeficiency virus (HIV) infection in southern Taiwan. For 562 IDUs (265 anti-HIV negative, 297 anti-HIV positive), we analyzed liver function, anti-HIV antibody, anti-HCV antibody, HCV viral loads, and hepatitis B surface antigen (HBsAg). HIV RNA viral loads and CD4 cell count for anti-HIV-seropositive IDUs and the HCV genotype for HCV RNA-seropositive IDUs were measured. The seroprevalence rates of anti-HIV, anti-HCV, and HBsAg were 52.8%, 91.3%, and 15.3%, respectively. All the anti-HIV-seropositive IDUs were positive for HIV RNA. Anti-HCV seropositivity was the most important factor associated with HIV infection (odds ratio [OR], 25.06; 95% confidence intervals [CI], 8.97-74.9), followed by male gender (OR, 6.12; 95% CI, 4.05-9.39) and HBsAg seropositivity (OR, 1.90; 95% CI, 1.11-3.34). Among IDUs positive for anti-HCV, 80.7% had detectable HCV RNA. HCV viremia after HCV exposure was strongly related to HIV infection (OR, 6.262; 95% CI, 1.515-18.28), but negatively correlated to HBsAg seropositivity (OR, 0.161; 95% CI, 0.082-0.317). HCV genotype 6 was the most prevalent genotype among all IDUs (41.0%), followed by genotypes 1 (32.3%), 3 (12.8%), and 2 (5.6%). In conclusion, about half IDUs were infected with HIV and >90% with HCV infection. Male and seropositivity for HBsAg and anti-HCV were factors related to HIV infection among our IDUs. HIV was positively correlated, whereas hepatitis B co-infection was negatively correlated with HCV viremia among IDUs with HCV exposure. Different HCV molecular epidemiology was noted among IDUs.http://europepmc.org/articles/PMC3983255?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Meng-Hsuan Hsieh Jih-Jin Tsai Ming-Yen Hsieh Chung-Feng Huang Ming-Lun Yeh Jeng-Fu Yang Ko Chang Wei-Ru Lin Chun-Yu Lin Tun-Chieh Chen Jee-Fu Huang Chia-Yen Dai Ming-Lung Yu Wan-Long Chuang |
spellingShingle |
Meng-Hsuan Hsieh Jih-Jin Tsai Ming-Yen Hsieh Chung-Feng Huang Ming-Lun Yeh Jeng-Fu Yang Ko Chang Wei-Ru Lin Chun-Yu Lin Tun-Chieh Chen Jee-Fu Huang Chia-Yen Dai Ming-Lung Yu Wan-Long Chuang Hepatitis C virus infection among injection drug users with and without human immunodeficiency virus co-infection. PLoS ONE |
author_facet |
Meng-Hsuan Hsieh Jih-Jin Tsai Ming-Yen Hsieh Chung-Feng Huang Ming-Lun Yeh Jeng-Fu Yang Ko Chang Wei-Ru Lin Chun-Yu Lin Tun-Chieh Chen Jee-Fu Huang Chia-Yen Dai Ming-Lung Yu Wan-Long Chuang |
author_sort |
Meng-Hsuan Hsieh |
title |
Hepatitis C virus infection among injection drug users with and without human immunodeficiency virus co-infection. |
title_short |
Hepatitis C virus infection among injection drug users with and without human immunodeficiency virus co-infection. |
title_full |
Hepatitis C virus infection among injection drug users with and without human immunodeficiency virus co-infection. |
title_fullStr |
Hepatitis C virus infection among injection drug users with and without human immunodeficiency virus co-infection. |
title_full_unstemmed |
Hepatitis C virus infection among injection drug users with and without human immunodeficiency virus co-infection. |
title_sort |
hepatitis c virus infection among injection drug users with and without human immunodeficiency virus co-infection. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
The aim of this study is to explore the prevalence of hepatitis C virus (HCV) infection among injection drug users (IDUs) with and without human immunodeficiency virus (HIV) infection in southern Taiwan. For 562 IDUs (265 anti-HIV negative, 297 anti-HIV positive), we analyzed liver function, anti-HIV antibody, anti-HCV antibody, HCV viral loads, and hepatitis B surface antigen (HBsAg). HIV RNA viral loads and CD4 cell count for anti-HIV-seropositive IDUs and the HCV genotype for HCV RNA-seropositive IDUs were measured. The seroprevalence rates of anti-HIV, anti-HCV, and HBsAg were 52.8%, 91.3%, and 15.3%, respectively. All the anti-HIV-seropositive IDUs were positive for HIV RNA. Anti-HCV seropositivity was the most important factor associated with HIV infection (odds ratio [OR], 25.06; 95% confidence intervals [CI], 8.97-74.9), followed by male gender (OR, 6.12; 95% CI, 4.05-9.39) and HBsAg seropositivity (OR, 1.90; 95% CI, 1.11-3.34). Among IDUs positive for anti-HCV, 80.7% had detectable HCV RNA. HCV viremia after HCV exposure was strongly related to HIV infection (OR, 6.262; 95% CI, 1.515-18.28), but negatively correlated to HBsAg seropositivity (OR, 0.161; 95% CI, 0.082-0.317). HCV genotype 6 was the most prevalent genotype among all IDUs (41.0%), followed by genotypes 1 (32.3%), 3 (12.8%), and 2 (5.6%). In conclusion, about half IDUs were infected with HIV and >90% with HCV infection. Male and seropositivity for HBsAg and anti-HCV were factors related to HIV infection among our IDUs. HIV was positively correlated, whereas hepatitis B co-infection was negatively correlated with HCV viremia among IDUs with HCV exposure. Different HCV molecular epidemiology was noted among IDUs. |
url |
http://europepmc.org/articles/PMC3983255?pdf=render |
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