Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis

Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis

Tuberculosis (TB) is an important disease that causes thousands of deaths around the world. Resistance against antitubercular available drugs has been reported; so, research on new effective antimycobacterial molecules is needed. Antimycobacterial activity of three lignans and two synthetic hydrazon...

Full description

Bibliographic Details
Main Authors: Eduard Baquero, Wiston Quiñones, Wellman Ribon, Maria Leonor Caldas, Ladys Sarmiento, Fernando Echeverri
Format: Article
Language:English
Published: Hindawi Limited 2011-01-01
Series:Tuberculosis Research and Treatment
Online Access:http://dx.doi.org/10.1155/2011/986409
id doaj-6350fe60911045ea862e36a6f004718c
record_format Article
spelling doaj-6350fe60911045ea862e36a6f004718c2020-11-24T23:17:08ZengHindawi LimitedTuberculosis Research and Treatment2090-150X2090-15182011-01-01201110.1155/2011/986409986409Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosisEduard Baquero0Wiston Quiñones1Wellman Ribon2Maria Leonor Caldas3Ladys Sarmiento4Fernando Echeverri5Grupo de Química Orgánica de Productos Naturales, Instituto de Química, Universidad de Antioquia, Carrera 53 No. 61-30, Laboratorio 234, Medellín 50010, ColombiaGrupo de Química Orgánica de Productos Naturales, Instituto de Química, Universidad de Antioquia, Carrera 53 No. 61-30, Laboratorio 234, Medellín 50010, ColombiaGrupo Micobacterias, Instituto Nacional de Salud, Bogotá 11001, D.C., ColombiaGrupo Microscopia y Análisis de Imágenes, Instituto Nacional de Salud, Bogotá 11001, D.C., ColombiaGrupo Microscopia y Análisis de Imágenes, Instituto Nacional de Salud, Bogotá 11001, D.C., ColombiaGrupo de Química Orgánica de Productos Naturales, Instituto de Química, Universidad de Antioquia, Carrera 53 No. 61-30, Laboratorio 234, Medellín 50010, ColombiaTuberculosis (TB) is an important disease that causes thousands of deaths around the world. Resistance against antitubercular available drugs has been reported; so, research on new effective antimycobacterial molecules is needed. Antimycobacterial activity of three lignans and two synthetic hydrazones was assessed against Mycobacterium tuberculosis H37Rv by antimycobacterial microdilution assay (TEMA). An oxadiazoline (AC451) and a lignan (ethoxycubebin) were the most active compounds (MIC 6.09 and 62.4 μM, resp.). Several changes in mycolic acid profile of treated bacteria were detected with both compounds by mass spectrometry analysis. Additionally, the level of reduction of mycolic acids in ethoxycubebin treatment was correlated to disruption in bacterial morphology.http://dx.doi.org/10.1155/2011/986409
collection DOAJ
language English
format Article
sources DOAJ
author Eduard Baquero
Wiston Quiñones
Wellman Ribon
Maria Leonor Caldas
Ladys Sarmiento
Fernando Echeverri
spellingShingle Eduard Baquero
Wiston Quiñones
Wellman Ribon
Maria Leonor Caldas
Ladys Sarmiento
Fernando Echeverri
Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis
Tuberculosis Research and Treatment
author_facet Eduard Baquero
Wiston Quiñones
Wellman Ribon
Maria Leonor Caldas
Ladys Sarmiento
Fernando Echeverri
author_sort Eduard Baquero
title Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis
title_short Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis
title_full Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis
title_fullStr Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis
title_full_unstemmed Effect of an Oxadiazoline and a Lignan on Mycolic Acid Biosynthesis and Ultrastructural Changes of Mycobacterium tuberculosis
title_sort effect of an oxadiazoline and a lignan on mycolic acid biosynthesis and ultrastructural changes of mycobacterium tuberculosis
publisher Hindawi Limited
series Tuberculosis Research and Treatment
issn 2090-150X
2090-1518
publishDate 2011-01-01
description Tuberculosis (TB) is an important disease that causes thousands of deaths around the world. Resistance against antitubercular available drugs has been reported; so, research on new effective antimycobacterial molecules is needed. Antimycobacterial activity of three lignans and two synthetic hydrazones was assessed against Mycobacterium tuberculosis H37Rv by antimycobacterial microdilution assay (TEMA). An oxadiazoline (AC451) and a lignan (ethoxycubebin) were the most active compounds (MIC 6.09 and 62.4 μM, resp.). Several changes in mycolic acid profile of treated bacteria were detected with both compounds by mass spectrometry analysis. Additionally, the level of reduction of mycolic acids in ethoxycubebin treatment was correlated to disruption in bacterial morphology.
url http://dx.doi.org/10.1155/2011/986409
work_keys_str_mv AT eduardbaquero effectofanoxadiazolineandalignanonmycolicacidbiosynthesisandultrastructuralchangesofmycobacteriumtuberculosis
AT wistonquinones effectofanoxadiazolineandalignanonmycolicacidbiosynthesisandultrastructuralchangesofmycobacteriumtuberculosis
AT wellmanribon effectofanoxadiazolineandalignanonmycolicacidbiosynthesisandultrastructuralchangesofmycobacteriumtuberculosis
AT marialeonorcaldas effectofanoxadiazolineandalignanonmycolicacidbiosynthesisandultrastructuralchangesofmycobacteriumtuberculosis
AT ladyssarmiento effectofanoxadiazolineandalignanonmycolicacidbiosynthesisandultrastructuralchangesofmycobacteriumtuberculosis
AT fernandoecheverri effectofanoxadiazolineandalignanonmycolicacidbiosynthesisandultrastructuralchangesofmycobacteriumtuberculosis
_version_ 1725584641404960768

Similar Items