Cyclosporine Biosynthesis in Tolypocladium inflatum Benefits Fungal Adaptation to the Environment

Cyclosporine Biosynthesis in Tolypocladium inflatum Benefits Fungal Adaptation to the Environment

The cyclopeptide cyclosporin A was first isolated from the filamentous fungus Tolypocladium inflatum showing antifungal activity and was later developed as an immunosuppressant drug. We report the biosynthetic mechanism of cyclosporines that are mediated by a cluster of genes encoding NRPS and PKS c...

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Bibliographic Details
Main Authors: Xiuqing Yang, Peng Feng, Ying Yin, Kathryn Bushley, Joseph W. Spatafora, Chengshu Wang
Format: Article
Language:English
Published: American Society for Microbiology 2018-10-01
Series:mBio
Subjects:
cyclosporine
Tolypocladium inflatum
antifungal activity
biosynthetic pathway
virulence
Online Access:https://doi.org/10.1128/mBio.01211-18

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