Annexin A1 Bioactive Peptide Promotes Resolution of Neuroinflammation in a Rat Model of Exsanguinating Cardiac Arrest Treated by Emergency Preservation and Resuscitation

Annexin A1 Bioactive Peptide Promotes Resolution of Neuroinflammation in a Rat Model of Exsanguinating Cardiac Arrest Treated by Emergency Preservation and Resuscitation

Neuroinflammation initiated by damage-associated molecular patterns, including high mobility group box 1 protein (HMGB1), has been implicated in adverse neurological outcomes following lethal hemorrhagic shock and polytrauma. Emergency preservation and resuscitation (EPR) is a novel method of resusc...

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Bibliographic Details
Main Authors: Qing Ma, Zhiquan Zhang, Jae-Kwang Shim, Talaignair N. Venkatraman, Christopher D. Lascola, Quintin J. Quinones, Joseph P. Mathew, Niccolò Terrando, Mihai V. Podgoreanu
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Neuroscience
Subjects:
sirtuins
autophagy
apoptosis
neuroprotection
HMGB1
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2019.00608/full

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