Metabolic control of cell division in α-proteobacteria by a NAD-dependent glutamate dehydrogenase

Metabolic control of cell division in α-proteobacteria by a NAD-dependent glutamate dehydrogenase

Prior to initiate energy-consuming processes, such as DNA replication or cell division, cells need to evaluate their metabolic status. We have recently identified and characterized a new connection between metabolism and cell division in the α-proteobacterium Caulobacter crescentus. We showed that a...

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Bibliographic Details
Main Authors: François Beaufay, Xavier De Bolle, Régis Hallez
Format: Article
Language:English
Published: Taylor & Francis Group 2016-01-01
Series:Communicative & Integrative Biology
Subjects:
α-proteobacteria
Brucella
Caulobacter
cytokinesis
cell division
FstZ
glutamate dehydrogenase
GdhZ
Online Access:http://dx.doi.org/10.1080/19420889.2015.1125052
Description
Summary:Prior to initiate energy-consuming processes, such as DNA replication or cell division, cells need to evaluate their metabolic status. We have recently identified and characterized a new connection between metabolism and cell division in the α-proteobacterium Caulobacter crescentus. We showed that an NAD-dependent glutamate dehydrogenase (GdhZ) coordinates growth with cell division according to its enzymatic activity. Here we report the conserved role of GdhZ in controlling cell division in another α-proteobacterium, the facultative intracellular pathogen Brucella abortus. We also discuss the importance of amino acids as a main carbon source for α-proteobacteria.
ISSN:1942-0889

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