Albendazole alone vs. albendazole and diethylcarbamazine combination therapy for trichuriasis
Background Trichuris trichiura is one of the most common soil-transmitted helminths, estimated to infect l billion people worldwide. Several studies have compared the efficacies of albendazole and diethylcarbamazine, but the efficacy of a combination of these two drugs has been inconclusive. Objecti...
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doaj-6366e343e8c64d3cb3686d03b654187a2020-11-25T00:41:12ZengIndonesian Pediatric Society Publishing HousePaediatrica Indonesiana0030-93112338-476X2014-04-015421091310.14238/pi54.2.2014.109-13133Albendazole alone vs. albendazole and diethylcarbamazine combination therapy for trichuriasisWindya Sari Nasution0Muhammad Ali1Ayodhia Pitaloka Pasaribu2Syahril Pasaribu3Chairuddin P. Lubis4University of Sumatera Utara Medical School, H. Adam Malik HospitalUniversity of Sumatera Utara Medical School, H. Adam Malik HospitalUniversity of Sumatera Utara Medical School, H. Adam Malik HospitalUniversity of Sumatera Utara Medical School, H. Adam Malik HospitalUniversity of Sumatera Utara Medical School, H. Adam Malik HospitalBackground Trichuris trichiura is one of the most common soil-transmitted helminths, estimated to infect l billion people worldwide. Several studies have compared the efficacies of albendazole and diethylcarbamazine, but the efficacy of a combination of these two drugs has been inconclusive. Objective To assess the effectiveness of a single dose of albendazole compared to a combination of albendazole and diethylcarbamazine for trichuriasis treatment. Methods A randomized, clinical open trial was conducted from June to September 2009 on elementary school children with trichuriasis from two villages in the North Sumatera Province. Stool specimens were collected at baseline and at days 7, 14, 21, and 28 after treatment, and examined by the Kato Katz method. Subjects were randomized into two groups. Group I received a single dose of albendazole (400 mg) and group II received albendazole (400 mg) plus diethylcarbamazine (6 mg! kg). Statistical analyses used were Chi square test for cure rates and Wilcoxon rank test for egg reduction rates. Results One hundred eight children were enrolled and randomized into group l (53 children) and group II (55 children). The prevalence of T. trichiura infection was 54.7%. There were no significant differences (P=0.52) in the cure rate between groups I and II (66% and 60%, respectively) or in egg reduction rates at day 28 (54.5% and 60.07%, respectively, P= 0.10). Conclusion Albendazole alone and abendazole combined with diethylcarbamazine have similar efficacies for trichuriasis treatment, in terms of cure rates and egg reduction rates.https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/216albendazole, diethylcarbamaz ine, trichuriasis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Windya Sari Nasution Muhammad Ali Ayodhia Pitaloka Pasaribu Syahril Pasaribu Chairuddin P. Lubis |
spellingShingle |
Windya Sari Nasution Muhammad Ali Ayodhia Pitaloka Pasaribu Syahril Pasaribu Chairuddin P. Lubis Albendazole alone vs. albendazole and diethylcarbamazine combination therapy for trichuriasis Paediatrica Indonesiana albendazole, diethylcarbamaz ine, trichuriasis |
author_facet |
Windya Sari Nasution Muhammad Ali Ayodhia Pitaloka Pasaribu Syahril Pasaribu Chairuddin P. Lubis |
author_sort |
Windya Sari Nasution |
title |
Albendazole alone vs. albendazole and diethylcarbamazine combination therapy for trichuriasis |
title_short |
Albendazole alone vs. albendazole and diethylcarbamazine combination therapy for trichuriasis |
title_full |
Albendazole alone vs. albendazole and diethylcarbamazine combination therapy for trichuriasis |
title_fullStr |
Albendazole alone vs. albendazole and diethylcarbamazine combination therapy for trichuriasis |
title_full_unstemmed |
Albendazole alone vs. albendazole and diethylcarbamazine combination therapy for trichuriasis |
title_sort |
albendazole alone vs. albendazole and diethylcarbamazine combination therapy for trichuriasis |
publisher |
Indonesian Pediatric Society Publishing House |
series |
Paediatrica Indonesiana |
issn |
0030-9311 2338-476X |
publishDate |
2014-04-01 |
description |
Background Trichuris trichiura is one of the most common
soil-transmitted helminths, estimated to infect l billion people
worldwide. Several studies have compared the efficacies of
albendazole and diethylcarbamazine, but the efficacy of a
combination of these two drugs has been inconclusive.
Objective To assess the effectiveness of a single dose of
albendazole compared to a combination of albendazole and
diethylcarbamazine for trichuriasis treatment.
Methods A randomized, clinical open trial was conducted from
June to September 2009 on elementary school children with
trichuriasis from two villages in the North Sumatera Province.
Stool specimens were collected at baseline and at days 7, 14,
21, and 28 after treatment, and examined by the Kato Katz
method. Subjects were randomized into two groups. Group I
received a single dose of albendazole (400 mg) and group II
received albendazole (400 mg) plus diethylcarbamazine (6 mg!
kg). Statistical analyses used were Chi square test for cure rates
and Wilcoxon rank test for egg reduction rates.
Results One hundred eight children were enrolled and
randomized into group l (53 children) and group II (55
children). The prevalence of T. trichiura infection was 54.7%.
There were no significant differences (P=0.52) in the cure
rate between groups I and II (66% and 60%, respectively) or in
egg reduction rates at day 28 (54.5% and 60.07%, respectively,
P= 0.10).
Conclusion Albendazole alone and abendazole combined
with diethylcarbamazine have similar efficacies for trichuriasis
treatment, in terms of cure rates and egg reduction rates. |
topic |
albendazole, diethylcarbamaz ine, trichuriasis |
url |
https://paediatricaindonesiana.org/index.php/paediatrica-indonesiana/article/view/216 |
work_keys_str_mv |
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