Bacterial vaginosis in spontaneous preterm and term birth: A case–control study
Background: Bacterial vaginosis (BV) is associated with adverse pregnancy outcomes, especially preterm birth (PTB). Unfortunately, there is a dearth of evidence on the link between BV and PTB occurring in sub-Saharan Africa to inform preventive interventions targeting BV associated with PTB. Objecti...
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Wolters Kluwer Medknow Publications
2016-01-01
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Online Access: | http://www.tjogonline.com/article.asp?issn=0189-5117;year=2016;volume=33;issue=3;spage=297;epage=301;aulast=Aderoba |
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doaj-6372e61fded243e18b6a8c97794f70a32020-11-24T21:36:20ZengWolters Kluwer Medknow PublicationsTropical Journal of Obstetrics and Gynaecology0189-51172016-01-0133329730110.4103/0189-5117.199820Bacterial vaginosis in spontaneous preterm and term birth: A case–control studyAdeniyi Kolade AderobaOghenefegor Edwin OlokorBiodun Nelson OlagbujiAdedapo Babatunde AndeChukwuwendu Anthony OkonkwoChiedozie Kingsley OjideBackground: Bacterial vaginosis (BV) is associated with adverse pregnancy outcomes, especially preterm birth (PTB). Unfortunately, there is a dearth of evidence on the link between BV and PTB occurring in sub-Saharan Africa to inform preventive interventions targeting BV associated with PTB. Objectives: The objective of this study was to evaluate the association between genital tract colonization with BV and PTB. Methods: In this prospective case–control study design, 82 women with spontaneous PTB (cases) or term birth (TB) (controls) were screened for BV. The diagnosis of BV was based on the Nugent scoring system. The association between BV and PTB was evaluated using multivariate logistic regression analysis. Results: BV was significantly higher in women with PTB compared with those with TB (17 [41.5%] vs. 5 [12.2%]; P= 0.005). Furthermore, the odds of BV with PTB were higher among women who had PTB compared with TB after adjusting for a known factor, marital status, which differed significantly between women with preterm and TB (adjusted odds ratio 4.5, 95% confidence interval [1.4–14.4]). Conclusion: Women with BV in pregnancy have increased odds of having PTB. Given the challenge of preterm labor and PTB, screening and treatment of women for BV early in pregnancy may be a veritable strategy to prevent PTB and its consequences.http://www.tjogonline.com/article.asp?issn=0189-5117;year=2016;volume=33;issue=3;spage=297;epage=301;aulast=AderobaBacterial vaginosis; Nigeria; pregnancy; preterm birth; term birth. |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Adeniyi Kolade Aderoba Oghenefegor Edwin Olokor Biodun Nelson Olagbuji Adedapo Babatunde Ande Chukwuwendu Anthony Okonkwo Chiedozie Kingsley Ojide |
spellingShingle |
Adeniyi Kolade Aderoba Oghenefegor Edwin Olokor Biodun Nelson Olagbuji Adedapo Babatunde Ande Chukwuwendu Anthony Okonkwo Chiedozie Kingsley Ojide Bacterial vaginosis in spontaneous preterm and term birth: A case–control study Tropical Journal of Obstetrics and Gynaecology Bacterial vaginosis; Nigeria; pregnancy; preterm birth; term birth. |
author_facet |
Adeniyi Kolade Aderoba Oghenefegor Edwin Olokor Biodun Nelson Olagbuji Adedapo Babatunde Ande Chukwuwendu Anthony Okonkwo Chiedozie Kingsley Ojide |
author_sort |
Adeniyi Kolade Aderoba |
title |
Bacterial vaginosis in spontaneous preterm and term birth: A case–control study |
title_short |
Bacterial vaginosis in spontaneous preterm and term birth: A case–control study |
title_full |
Bacterial vaginosis in spontaneous preterm and term birth: A case–control study |
title_fullStr |
Bacterial vaginosis in spontaneous preterm and term birth: A case–control study |
title_full_unstemmed |
Bacterial vaginosis in spontaneous preterm and term birth: A case–control study |
title_sort |
bacterial vaginosis in spontaneous preterm and term birth: a case–control study |
publisher |
Wolters Kluwer Medknow Publications |
series |
Tropical Journal of Obstetrics and Gynaecology |
issn |
0189-5117 |
publishDate |
2016-01-01 |
description |
Background: Bacterial vaginosis (BV) is associated with adverse pregnancy outcomes, especially preterm birth (PTB). Unfortunately, there is a dearth of evidence on the link between BV and PTB occurring in sub-Saharan Africa to inform preventive interventions targeting BV associated with PTB.
Objectives: The objective of this study was to evaluate the association between genital tract colonization with BV and PTB.
Methods: In this prospective case–control study design, 82 women with spontaneous PTB (cases) or term birth (TB) (controls) were screened for BV. The diagnosis of BV was based on the Nugent scoring system. The association between BV and PTB was evaluated using multivariate logistic regression analysis.
Results: BV was significantly higher in women with PTB compared with those with TB (17 [41.5%] vs. 5 [12.2%]; P= 0.005). Furthermore, the odds of BV with PTB were higher among women who had PTB compared with TB after adjusting for a known factor, marital status, which differed significantly between women with preterm and TB (adjusted odds ratio 4.5, 95% confidence interval [1.4–14.4]).
Conclusion: Women with BV in pregnancy have increased odds of having PTB. Given the challenge of preterm labor and PTB, screening and treatment of women for BV early in pregnancy may be a veritable strategy to prevent PTB and its consequences. |
topic |
Bacterial vaginosis; Nigeria; pregnancy; preterm birth; term birth. |
url |
http://www.tjogonline.com/article.asp?issn=0189-5117;year=2016;volume=33;issue=3;spage=297;epage=301;aulast=Aderoba |
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