Regenerated <i>Antheraea pernyi</i> Silk Fibroin/Poly(<i>N</i>-isopropylacrylamide) Thermosensitive Composite Hydrogel with Improved Mechanical Strength
At present, <i>Antheraea pernyi</i> silk fibroin (ASF) has attracted research efforts to investigate it as a raw material for fabrication of biomedical devices because of its superior cytocompatibility. Nevertheless, native ASF is not easily processed into a hydrogel without any crosslin...
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doaj-639f98503f334a50a432e35f115854842020-11-25T01:14:21ZengMDPI AGPolymers2073-43602019-02-0111230210.3390/polym11020302polym11020302Regenerated <i>Antheraea pernyi</i> Silk Fibroin/Poly(<i>N</i>-isopropylacrylamide) Thermosensitive Composite Hydrogel with Improved Mechanical StrengthBoxiang Wang0Song Zhang1Yifan Wang2Bo Si3Dehong Cheng4Li Liu5Yanhua Lu6School of Materials Science and Engineering, Shanghai University, Shanghai 200444, ChinaSchool of Materials Science and Engineering, Shanghai University, Shanghai 200444, ChinaSchool of Materials Science and Engineering, Shanghai University, Shanghai 200444, ChinaSchool of Chemical Engineering, Eastern Liaoning University, Eastern Liaoning University, Dandong 118003, ChinaKey Laboratory of Functional Textile Materials, Liaoning Province, Eastern Liaoning University, Dandong 118003, ChinaSchool of Materials Science and Engineering, Shanghai University, Shanghai 200444, ChinaKey Laboratory of Functional Textile Materials, Liaoning Province, Eastern Liaoning University, Dandong 118003, ChinaAt present, <i>Antheraea pernyi</i> silk fibroin (ASF) has attracted research efforts to investigate it as a raw material for fabrication of biomedical devices because of its superior cytocompatibility. Nevertheless, native ASF is not easily processed into a hydrogel without any crosslinking agent, and a single hydrogel shows poor mechanical properties. In this paper, a series of ASF/poly (N-isopropylacrylamide) (PNIPAAm) composite hydrogels with different ASF contents were manufactured by a simple in situ polymerization method without any crosslinking agent. Meanwhile, the structures, morphologies and thermal properties of composite hydrogels were investigated by XRD, FTIR, SEM, DSC and TGA, respectively. The results indicate that the secondary structure of silk in the composite hydrogel can be controlled by changing the ASF content and the thermal stability of composite hydrogels is enhanced with an increase in crystalline structure. The composite hydrogels showed similar lower critical solution temperatures (LCST) at about 32 °C, which matched well with the LCST of PNIPAAm. Finally, the obtained thermosensitive composite hydrogels exhibited enhanced mechanical properties, which can be tuned by varying the content of ASF. This strategy to prepare an ASF-based responsive composite hydrogel with enhanced mechanical properties represents a valuable route for developing the fields of ASF, and, furthermore, their attractive applications can meet the needs of different biomaterial fields.https://www.mdpi.com/2073-4360/11/2/302<i>Antheraea pernyi</i>silk fibroinhydrogelthermosensitivemechanical properties |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Boxiang Wang Song Zhang Yifan Wang Bo Si Dehong Cheng Li Liu Yanhua Lu |
spellingShingle |
Boxiang Wang Song Zhang Yifan Wang Bo Si Dehong Cheng Li Liu Yanhua Lu Regenerated <i>Antheraea pernyi</i> Silk Fibroin/Poly(<i>N</i>-isopropylacrylamide) Thermosensitive Composite Hydrogel with Improved Mechanical Strength Polymers <i>Antheraea pernyi</i> silk fibroin hydrogel thermosensitive mechanical properties |
author_facet |
Boxiang Wang Song Zhang Yifan Wang Bo Si Dehong Cheng Li Liu Yanhua Lu |
author_sort |
Boxiang Wang |
title |
Regenerated <i>Antheraea pernyi</i> Silk Fibroin/Poly(<i>N</i>-isopropylacrylamide) Thermosensitive Composite Hydrogel with Improved Mechanical Strength |
title_short |
Regenerated <i>Antheraea pernyi</i> Silk Fibroin/Poly(<i>N</i>-isopropylacrylamide) Thermosensitive Composite Hydrogel with Improved Mechanical Strength |
title_full |
Regenerated <i>Antheraea pernyi</i> Silk Fibroin/Poly(<i>N</i>-isopropylacrylamide) Thermosensitive Composite Hydrogel with Improved Mechanical Strength |
title_fullStr |
Regenerated <i>Antheraea pernyi</i> Silk Fibroin/Poly(<i>N</i>-isopropylacrylamide) Thermosensitive Composite Hydrogel with Improved Mechanical Strength |
title_full_unstemmed |
Regenerated <i>Antheraea pernyi</i> Silk Fibroin/Poly(<i>N</i>-isopropylacrylamide) Thermosensitive Composite Hydrogel with Improved Mechanical Strength |
title_sort |
regenerated <i>antheraea pernyi</i> silk fibroin/poly(<i>n</i>-isopropylacrylamide) thermosensitive composite hydrogel with improved mechanical strength |
publisher |
MDPI AG |
series |
Polymers |
issn |
2073-4360 |
publishDate |
2019-02-01 |
description |
At present, <i>Antheraea pernyi</i> silk fibroin (ASF) has attracted research efforts to investigate it as a raw material for fabrication of biomedical devices because of its superior cytocompatibility. Nevertheless, native ASF is not easily processed into a hydrogel without any crosslinking agent, and a single hydrogel shows poor mechanical properties. In this paper, a series of ASF/poly (N-isopropylacrylamide) (PNIPAAm) composite hydrogels with different ASF contents were manufactured by a simple in situ polymerization method without any crosslinking agent. Meanwhile, the structures, morphologies and thermal properties of composite hydrogels were investigated by XRD, FTIR, SEM, DSC and TGA, respectively. The results indicate that the secondary structure of silk in the composite hydrogel can be controlled by changing the ASF content and the thermal stability of composite hydrogels is enhanced with an increase in crystalline structure. The composite hydrogels showed similar lower critical solution temperatures (LCST) at about 32 °C, which matched well with the LCST of PNIPAAm. Finally, the obtained thermosensitive composite hydrogels exhibited enhanced mechanical properties, which can be tuned by varying the content of ASF. This strategy to prepare an ASF-based responsive composite hydrogel with enhanced mechanical properties represents a valuable route for developing the fields of ASF, and, furthermore, their attractive applications can meet the needs of different biomaterial fields. |
topic |
<i>Antheraea pernyi</i> silk fibroin hydrogel thermosensitive mechanical properties |
url |
https://www.mdpi.com/2073-4360/11/2/302 |
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