Ex vivo Hsp70-Activated NK Cells in Combination With PD-1 Inhibition Significantly Increase Overall Survival in Preclinical Models of Glioblastoma and Lung Cancer

Ex vivo Hsp70-Activated NK Cells in Combination With PD-1 Inhibition Significantly Increase Overall Survival in Preclinical Models of Glioblastoma and Lung Cancer

Heat shock protein 70 (Hsp70) which is expressed on the plasma membrane of highly aggressive tumors including non-small cell lung carcinoma and glioblastoma multiforme serves as a target for Hsp70-targeting NK cells. Herein, we aimed to investigate the antitumor effects of a combined therapy consist...

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Bibliographic Details
Main Authors: Maxim Shevtsov, Emil Pitkin, Alexander Ischenko, Stefan Stangl, William Khachatryan, Oleg Galibin, Stanley Edmond, Dominik Lobinger, Gabriele Multhoff
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
membrane Hsp70
glioblastoma
lung carcinoma
immunophenotyping
NK cell therapy
anti-PD-1 antibody
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00454/full

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