Oxytocin and arginine vasopressin receptor evolution: implications for adaptive novelties in placental mammals
Abstract Oxytocin receptor (OXTR) and arginine vasopressin receptors (AVPR1a, AVPR1b, and AVPR2) are paralogous genes that emerged through duplication events; along the evolutionary timeline, owing to speciation, numerous orthologues emerged as well. In order to elucidate the evolutionary forces tha...
Main Authors: | , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Sociedade Brasileira de Genética
|
Series: | Genetics and Molecular Biology |
Subjects: | |
Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000400646&lng=en&tlng=en |
id |
doaj-63ac7b39df6c40de8f97da4d63c3e2ca |
---|---|
record_format |
Article |
spelling |
doaj-63ac7b39df6c40de8f97da4d63c3e2ca2020-11-25T01:52:41ZengSociedade Brasileira de GenéticaGenetics and Molecular Biology1678-468539464665710.1590/1678-4685-gmb-2015-0323S1415-47572016000400646Oxytocin and arginine vasopressin receptor evolution: implications for adaptive novelties in placental mammalsPamela ParéVanessa R. Paixão-CôrtesLuciana Tovo-RodriguesPedro Vargas-PinillaLucas Henriques ViscardiFrancisco Mauro SalzanoLuiz E. HenkesMaria Catira BortoliniAbstract Oxytocin receptor (OXTR) and arginine vasopressin receptors (AVPR1a, AVPR1b, and AVPR2) are paralogous genes that emerged through duplication events; along the evolutionary timeline, owing to speciation, numerous orthologues emerged as well. In order to elucidate the evolutionary forces that shaped these four genes in placental mammals and to reveal specific aspects of their protein structures, 35 species were selected. Specifically, we investigated their molecular evolutionary history and intrinsic protein disorder content, and identified the presence of short linear interaction motifs. OXTR seems to be under evolutionary constraint in placental mammals, whereas AVPR1a, AVPR1b, and AVPR2 exhibit higher evolutionary rates, suggesting that they have been under relaxed or experienced positive selection. In addition, we describe here, for the first time, that the OXTR, AVPR1a, AVPR1b, and AVPR2 mammalian orthologues preserve their disorder content, while this condition varies among the paralogues. Finally, our results reveal the presence of short linear interaction motifs, indicating possible functional adaptations related to physiological and/or behavioral taxa-specific traits.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000400646&lng=en&tlng=enOxytocin receptorArginine vasopressin receptorsmolecular evolutionprotein disorderinteraction motifs |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pamela Paré Vanessa R. Paixão-Côrtes Luciana Tovo-Rodrigues Pedro Vargas-Pinilla Lucas Henriques Viscardi Francisco Mauro Salzano Luiz E. Henkes Maria Catira Bortolini |
spellingShingle |
Pamela Paré Vanessa R. Paixão-Côrtes Luciana Tovo-Rodrigues Pedro Vargas-Pinilla Lucas Henriques Viscardi Francisco Mauro Salzano Luiz E. Henkes Maria Catira Bortolini Oxytocin and arginine vasopressin receptor evolution: implications for adaptive novelties in placental mammals Genetics and Molecular Biology Oxytocin receptor Arginine vasopressin receptors molecular evolution protein disorder interaction motifs |
author_facet |
Pamela Paré Vanessa R. Paixão-Côrtes Luciana Tovo-Rodrigues Pedro Vargas-Pinilla Lucas Henriques Viscardi Francisco Mauro Salzano Luiz E. Henkes Maria Catira Bortolini |
author_sort |
Pamela Paré |
title |
Oxytocin and arginine vasopressin receptor evolution: implications for adaptive novelties in placental mammals |
title_short |
Oxytocin and arginine vasopressin receptor evolution: implications for adaptive novelties in placental mammals |
title_full |
Oxytocin and arginine vasopressin receptor evolution: implications for adaptive novelties in placental mammals |
title_fullStr |
Oxytocin and arginine vasopressin receptor evolution: implications for adaptive novelties in placental mammals |
title_full_unstemmed |
Oxytocin and arginine vasopressin receptor evolution: implications for adaptive novelties in placental mammals |
title_sort |
oxytocin and arginine vasopressin receptor evolution: implications for adaptive novelties in placental mammals |
publisher |
Sociedade Brasileira de Genética |
series |
Genetics and Molecular Biology |
issn |
1678-4685 |
description |
Abstract Oxytocin receptor (OXTR) and arginine vasopressin receptors (AVPR1a, AVPR1b, and AVPR2) are paralogous genes that emerged through duplication events; along the evolutionary timeline, owing to speciation, numerous orthologues emerged as well. In order to elucidate the evolutionary forces that shaped these four genes in placental mammals and to reveal specific aspects of their protein structures, 35 species were selected. Specifically, we investigated their molecular evolutionary history and intrinsic protein disorder content, and identified the presence of short linear interaction motifs. OXTR seems to be under evolutionary constraint in placental mammals, whereas AVPR1a, AVPR1b, and AVPR2 exhibit higher evolutionary rates, suggesting that they have been under relaxed or experienced positive selection. In addition, we describe here, for the first time, that the OXTR, AVPR1a, AVPR1b, and AVPR2 mammalian orthologues preserve their disorder content, while this condition varies among the paralogues. Finally, our results reveal the presence of short linear interaction motifs, indicating possible functional adaptations related to physiological and/or behavioral taxa-specific traits. |
topic |
Oxytocin receptor Arginine vasopressin receptors molecular evolution protein disorder interaction motifs |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572016000400646&lng=en&tlng=en |
work_keys_str_mv |
AT pamelapare oxytocinandargininevasopressinreceptorevolutionimplicationsforadaptivenoveltiesinplacentalmammals AT vanessarpaixaocortes oxytocinandargininevasopressinreceptorevolutionimplicationsforadaptivenoveltiesinplacentalmammals AT lucianatovorodrigues oxytocinandargininevasopressinreceptorevolutionimplicationsforadaptivenoveltiesinplacentalmammals AT pedrovargaspinilla oxytocinandargininevasopressinreceptorevolutionimplicationsforadaptivenoveltiesinplacentalmammals AT lucashenriquesviscardi oxytocinandargininevasopressinreceptorevolutionimplicationsforadaptivenoveltiesinplacentalmammals AT franciscomaurosalzano oxytocinandargininevasopressinreceptorevolutionimplicationsforadaptivenoveltiesinplacentalmammals AT luizehenkes oxytocinandargininevasopressinreceptorevolutionimplicationsforadaptivenoveltiesinplacentalmammals AT mariacatirabortolini oxytocinandargininevasopressinreceptorevolutionimplicationsforadaptivenoveltiesinplacentalmammals |
_version_ |
1724993726850269184 |