Functional roles of Mg2+ binding sites in ion-dependent gating of a Mg2+ channel, MgtE, revealed by solution NMR
Magnesium ions (Mg2+) are divalent cations essential for various cellular functions. Mg2+ homeostasis is maintained through Mg2+ channels such as MgtE, a prokaryotic Mg2+ channel whose gating is regulated by intracellular Mg2+ levels. Our previous crystal structure of MgtE in the Mg2+-bound, closed...
Main Authors: | Tatsuro Maruyama, Shunsuke Imai, Tsukasa Kusakizako, Motoyuki Hattori, Ryuichiro Ishitani, Osamu Nureki, Koichi Ito, Andrès D Maturana, Ichio Shimada, Masanori Osawa |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2018-04-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/31596 |
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