Deciphering Human Leukocyte Antigen Susceptibility Maps From Immunopeptidomics Characterization in Oncology and Infections
Genetic variability across the three major histocompatibility complex (MHC) class I genes (human leukocyte antigen [HLA] A, B, and C) may affect susceptibility to many diseases such as cancer, auto-immune or infectious diseases. Individual genetic variation may help to explain different immune respo...
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doaj-63bebe51404447109cf757f148c7cd5f2021-05-28T08:03:34ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-05-011110.3389/fcimb.2021.642583642583Deciphering Human Leukocyte Antigen Susceptibility Maps From Immunopeptidomics Characterization in Oncology and InfectionsPablo Juanes-Velasco0Alicia Landeira-Viñuela1Vanessa Acebes-Fernandez2Ángela-Patricia Hernández3Marina L. Garcia-Vaquero4Carlota Arias-Hidalgo5Halin Bareke6Enrique Montalvillo7Rafael Gongora8Manuel Fuentes9Manuel Fuentes10Department of Medicine and Cytometry General Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, SpainDepartment of Medicine and Cytometry General Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, SpainDepartment of Medicine and Cytometry General Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, SpainDepartment of Medicine and Cytometry General Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, SpainDepartment of Medicine and Cytometry General Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, SpainDepartment of Medicine and Cytometry General Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, SpainDepartment of Medicine and Cytometry General Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, SpainDepartment of Medicine and Cytometry General Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, SpainDepartment of Medicine and Cytometry General Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, SpainDepartment of Medicine and Cytometry General Service-Nucleus, CIBERONC, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, SpainProteomics Unit, Cancer Research Centre (IBMCC/CSIC/USAL/IBSAL), Salamanca, SpainGenetic variability across the three major histocompatibility complex (MHC) class I genes (human leukocyte antigen [HLA] A, B, and C) may affect susceptibility to many diseases such as cancer, auto-immune or infectious diseases. Individual genetic variation may help to explain different immune responses to microorganisms across a population. HLA typing can be fast and inexpensive; however, deciphering peptides loaded on MHC-I and II which are presented to T cells, require the design and development of high-sensitivity methodological approaches and subsequently databases. Hence, these novel strategies and databases could help in the generation of vaccines using these potential immunogenic peptides and in identifying high-risk HLA types to be prioritized for vaccination programs. Herein, the recent developments and approaches, in this field, focusing on the identification of immunogenic peptides have been reviewed and the next steps to promote their translation into biomedical and clinical practice are discussed.https://www.frontiersin.org/articles/10.3389/fcimb.2021.642583/fullimmunopeptidomicshuman leukocyte antigenimmunochromatographyproteomicsvaccines |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pablo Juanes-Velasco Alicia Landeira-Viñuela Vanessa Acebes-Fernandez Ángela-Patricia Hernández Marina L. Garcia-Vaquero Carlota Arias-Hidalgo Halin Bareke Enrique Montalvillo Rafael Gongora Manuel Fuentes Manuel Fuentes |
spellingShingle |
Pablo Juanes-Velasco Alicia Landeira-Viñuela Vanessa Acebes-Fernandez Ángela-Patricia Hernández Marina L. Garcia-Vaquero Carlota Arias-Hidalgo Halin Bareke Enrique Montalvillo Rafael Gongora Manuel Fuentes Manuel Fuentes Deciphering Human Leukocyte Antigen Susceptibility Maps From Immunopeptidomics Characterization in Oncology and Infections Frontiers in Cellular and Infection Microbiology immunopeptidomics human leukocyte antigen immunochromatography proteomics vaccines |
author_facet |
Pablo Juanes-Velasco Alicia Landeira-Viñuela Vanessa Acebes-Fernandez Ángela-Patricia Hernández Marina L. Garcia-Vaquero Carlota Arias-Hidalgo Halin Bareke Enrique Montalvillo Rafael Gongora Manuel Fuentes Manuel Fuentes |
author_sort |
Pablo Juanes-Velasco |
title |
Deciphering Human Leukocyte Antigen Susceptibility Maps From Immunopeptidomics Characterization in Oncology and Infections |
title_short |
Deciphering Human Leukocyte Antigen Susceptibility Maps From Immunopeptidomics Characterization in Oncology and Infections |
title_full |
Deciphering Human Leukocyte Antigen Susceptibility Maps From Immunopeptidomics Characterization in Oncology and Infections |
title_fullStr |
Deciphering Human Leukocyte Antigen Susceptibility Maps From Immunopeptidomics Characterization in Oncology and Infections |
title_full_unstemmed |
Deciphering Human Leukocyte Antigen Susceptibility Maps From Immunopeptidomics Characterization in Oncology and Infections |
title_sort |
deciphering human leukocyte antigen susceptibility maps from immunopeptidomics characterization in oncology and infections |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2021-05-01 |
description |
Genetic variability across the three major histocompatibility complex (MHC) class I genes (human leukocyte antigen [HLA] A, B, and C) may affect susceptibility to many diseases such as cancer, auto-immune or infectious diseases. Individual genetic variation may help to explain different immune responses to microorganisms across a population. HLA typing can be fast and inexpensive; however, deciphering peptides loaded on MHC-I and II which are presented to T cells, require the design and development of high-sensitivity methodological approaches and subsequently databases. Hence, these novel strategies and databases could help in the generation of vaccines using these potential immunogenic peptides and in identifying high-risk HLA types to be prioritized for vaccination programs. Herein, the recent developments and approaches, in this field, focusing on the identification of immunogenic peptides have been reviewed and the next steps to promote their translation into biomedical and clinical practice are discussed. |
topic |
immunopeptidomics human leukocyte antigen immunochromatography proteomics vaccines |
url |
https://www.frontiersin.org/articles/10.3389/fcimb.2021.642583/full |
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