Association between airborne particulate matter and renal function: An analysis of 2.5 million young adults
Background: Limited studies have examined the impact of airborne particulate matter of 2.5 μm or less (PM2.5) on renal function. No study has examined the effect of PM1, which is small enough to reach the blood circulation. We examined whether exposure to PM1 or PM2.5 affected renal function of youn...
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Elsevier
2021-02-01
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Series: | Environment International |
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Online Access: | http://www.sciencedirect.com/science/article/pii/S0160412020323035 |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Qin Li Yuan-Yuan Wang Yuming Guo Hong Zhou Qiao-Mei Wang Hai-Ping Shen Yi-Ping Zhang Dong-Hai Yan Shanshan Li Gongbo Chen Lizi Lin Yuan He Ying Yang Zuo-Qi Peng Hai-Jun Wang Xu Ma |
spellingShingle |
Qin Li Yuan-Yuan Wang Yuming Guo Hong Zhou Qiao-Mei Wang Hai-Ping Shen Yi-Ping Zhang Dong-Hai Yan Shanshan Li Gongbo Chen Lizi Lin Yuan He Ying Yang Zuo-Qi Peng Hai-Jun Wang Xu Ma Association between airborne particulate matter and renal function: An analysis of 2.5 million young adults Environment International PM1 PM2.5 Serum creatinine eGFR Young adults |
author_facet |
Qin Li Yuan-Yuan Wang Yuming Guo Hong Zhou Qiao-Mei Wang Hai-Ping Shen Yi-Ping Zhang Dong-Hai Yan Shanshan Li Gongbo Chen Lizi Lin Yuan He Ying Yang Zuo-Qi Peng Hai-Jun Wang Xu Ma |
author_sort |
Qin Li |
title |
Association between airborne particulate matter and renal function: An analysis of 2.5 million young adults |
title_short |
Association between airborne particulate matter and renal function: An analysis of 2.5 million young adults |
title_full |
Association between airborne particulate matter and renal function: An analysis of 2.5 million young adults |
title_fullStr |
Association between airborne particulate matter and renal function: An analysis of 2.5 million young adults |
title_full_unstemmed |
Association between airborne particulate matter and renal function: An analysis of 2.5 million young adults |
title_sort |
association between airborne particulate matter and renal function: an analysis of 2.5 million young adults |
publisher |
Elsevier |
series |
Environment International |
issn |
0160-4120 |
publishDate |
2021-02-01 |
description |
Background: Limited studies have examined the impact of airborne particulate matter of 2.5 μm or less (PM2.5) on renal function. No study has examined the effect of PM1, which is small enough to reach the blood circulation. We examined whether exposure to PM1 or PM2.5 affected renal function of young Han Chinese. Method: We included 2,546,047 young adults who were aged 18 to 45 years, being Han ethnicity and had no chronic disease from a Chinese national birth cohort. Serum creatinine (Scr) of each participant was measured during the baseline examination. Estimated glomerular filtration rate (eGFR) were calculated for each participant using the latest Chronic Kidney Disease Epidemiology Collaboration equation. One-year average exposure to PM1 and PM2.5 prior to the health examination for each participant were estimated using machine learning models with satellite remote sensing information. Generalized additive mixed models were used to estimate associations between PM1 or PM2.5 and renal function after adjusting for detailed individual variables. Results: A 10 μg/m3 increment in PM1 exposure was associated with −0.95% (95%CI: −1.04%, −0.87%) difference of eGFR in females and −0.37% (95%CI: −0.44%, −0.31%) in males. For PM2.5, the corresponding difference of eGFR was −0.99% (95%CI: −1.05%, −0.93%) in females and −0.48% (95%CI: −0.53%, −0.43%) in males, respectively. Associations between eGFR and PM were higher in females compared to males (p < 0.05 for interaction test). Association with PM1 were weaker than that with other fractions included in PM2.5. Participants who worked as farmers, were of normal weight, were not exposed to tobacco smoking, did not drink alcohol, had higher associations between eGFR and PM than their counterparts (p < 0.05 for interaction test). Conclusion: Exposure to PM1 and PM2.5 was associated with reduced renal function among Han Chinese at reproductive age. |
topic |
PM1 PM2.5 Serum creatinine eGFR Young adults |
url |
http://www.sciencedirect.com/science/article/pii/S0160412020323035 |
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doaj-63d2532ec62e473eb0faa9c23a6a1da22021-01-20T04:10:37ZengElsevierEnvironment International0160-41202021-02-01147106348Association between airborne particulate matter and renal function: An analysis of 2.5 million young adultsQin Li0Yuan-Yuan Wang1Yuming Guo2Hong Zhou3Qiao-Mei Wang4Hai-Ping Shen5Yi-Ping Zhang6Dong-Hai Yan7Shanshan Li8Gongbo Chen9Lizi Lin10Yuan He11Ying Yang12Zuo-Qi Peng13Hai-Jun Wang14Xu Ma15Department of Gynecology and Obstetrics, Peking University Third Hospital, Beijing, China; Environmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China; Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, ChinaEnvironmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China; National Research Institute for Family Planning, Beijing, ChinaDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, AustraliaEnvironmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China; Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, ChinaDepartment of Maternal and Child Health, National Health Commission of the PRC, Beijing, ChinaDepartment of Maternal and Child Health, National Health Commission of the PRC, Beijing, ChinaDepartment of Maternal and Child Health, National Health Commission of the PRC, Beijing, ChinaDepartment of Maternal and Child Health, National Health Commission of the PRC, Beijing, ChinaDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, AustraliaDepartment of Epidemiology and Preventive Medicine, School of Public Health and Preventive Medicine, Monash University, Melbourne, AustraliaDepartment of Maternal and Child Health, School of Public Health, Peking University, Beijing, ChinaNational Research Institute for Family Planning, Beijing, ChinaNational Research Institute for Family Planning, Beijing, ChinaNational Research Institute for Family Planning, Beijing, ChinaEnvironmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China; Department of Maternal and Child Health, School of Public Health, Peking University, Beijing, China; Corresponding author at: Department of Maternal and Child Health, School of Public Health, Peking University, No38. Xueyuan Rd, Beijing 100191, China (H. Wang). National Research Institute for Family Planning, No12. Dahuishi Rd, Beijing 100081, China (X. Ma).Environmental and Spatial Epidemiology Research Center, National Human Genetic Resources Center, Beijing, China; National Research Institute for Family Planning, Beijing, China; Corresponding author at: Department of Maternal and Child Health, School of Public Health, Peking University, No38. Xueyuan Rd, Beijing 100191, China (H. Wang). National Research Institute for Family Planning, No12. Dahuishi Rd, Beijing 100081, China (X. Ma).Background: Limited studies have examined the impact of airborne particulate matter of 2.5 μm or less (PM2.5) on renal function. No study has examined the effect of PM1, which is small enough to reach the blood circulation. We examined whether exposure to PM1 or PM2.5 affected renal function of young Han Chinese. Method: We included 2,546,047 young adults who were aged 18 to 45 years, being Han ethnicity and had no chronic disease from a Chinese national birth cohort. Serum creatinine (Scr) of each participant was measured during the baseline examination. Estimated glomerular filtration rate (eGFR) were calculated for each participant using the latest Chronic Kidney Disease Epidemiology Collaboration equation. One-year average exposure to PM1 and PM2.5 prior to the health examination for each participant were estimated using machine learning models with satellite remote sensing information. Generalized additive mixed models were used to estimate associations between PM1 or PM2.5 and renal function after adjusting for detailed individual variables. Results: A 10 μg/m3 increment in PM1 exposure was associated with −0.95% (95%CI: −1.04%, −0.87%) difference of eGFR in females and −0.37% (95%CI: −0.44%, −0.31%) in males. For PM2.5, the corresponding difference of eGFR was −0.99% (95%CI: −1.05%, −0.93%) in females and −0.48% (95%CI: −0.53%, −0.43%) in males, respectively. Associations between eGFR and PM were higher in females compared to males (p < 0.05 for interaction test). Association with PM1 were weaker than that with other fractions included in PM2.5. Participants who worked as farmers, were of normal weight, were not exposed to tobacco smoking, did not drink alcohol, had higher associations between eGFR and PM than their counterparts (p < 0.05 for interaction test). Conclusion: Exposure to PM1 and PM2.5 was associated with reduced renal function among Han Chinese at reproductive age.http://www.sciencedirect.com/science/article/pii/S0160412020323035PM1PM2.5Serum creatinineeGFRYoung adults |