Successful transplantation of kidneys from deceased donors with terminal acute kidney injury

• Main Authors: Piotr Domagala, Lukasz Gorski, Michal Wszola, Rafal Kieszek, Piotr Diuwe, Piotr Goralski, Jakub Drozdowski, Agata Ostaszewska, Jolanta Gozdowska, Michal Ciszek, Janusz Trzebicki, Magdalena Durlik, Leszek Paczek, Andrzej Chmura, Artur Kwiatkowski
• Format: Article
• Language: English
• Published: Taylor & Francis Group 2019-01-01
• Series: Renal Failure
• Subjects: acute kidney injury; deceased donors; expanded criteria donors; kidney graft survival; kidney transplantation
• Online Access: http://dx.doi.org/10.1080/0886022X.2019.1590209

Background: There are many doubts with regards to accepting deceased kidneys with acute kidney injury (AKI) for transplantation. Purpose: The aim of this study was to present the 5-years outcome of kidney transplantation cases where deceased donors developed AKI before organ procurement. Methods: Two hundred twenty-six deceased renal transplants were analyzed. Data regarding donors and recipients were collected. Terminal AKI was defined as terminal serum creatinine concentration higher than 1.99 mg/dL and 66 such cases were diagnosed. All kidney transplant recipients were followed for 60 months. Results: AKI group presented more episodes of delayed graft function (DGF) compared to the non-AKI group (56% vs 35%, p < .05). No differences were observed between the groups in the rate of acute rejection episodes, kidney function as well as patient and graft survival. Conclusions: Transplants with AKI present more often DGF and comparable graft survival to transplants without AKI. Kidneys with AKI can be a valuable source of organs provided attentive selection and appropriate care of deceased donors.