Study of transcriptional effects in Cis at the IFIH1 locus.
The Thr allele at the non-synonymous single-nucleotide polymorphism (nsSNP) Thr946Ala in the IFIH1 gene confers risk for Type 1 diabetes (T1D). The SNP is embedded in a 236 kb linkage disequilibrium (LD) block that includes four genes: IFIH1, GCA, FAP and KCNH7. The absence of common nsSNPs in the o...
Main Authors: | Hana Zouk, Luc Marchand, Constantin Polychronakos |
---|---|
Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2010-07-01
|
Series: | PLoS ONE |
Online Access: | http://europepmc.org/articles/PMC2903489?pdf=render |
Similar Items
-
The rs1990760 polymorphism within the IFIH1 locus is not associated with Graves' disease, Hashimoto's thyroiditis and Addison's disease
by: Seidl Christian, et al.
Published: (2009-12-01) -
Aicardi-Goutieres Syndrome is Caused by IFIH1 Mutations
by: Oda, Hirotsugu
Published: (2016) -
IFIH1 Contributes to M1 Macrophage Polarization in ARDS
by: Shi Zhang, et al.
Published: (2021-01-01) -
Reduced expression of IFIH1 is protective for type 1 diabetes.
by: Kate Downes, et al.
Published: (2010-09-01) -
Functional characterization of novel genetic loci associated with type 1 diabetes
by: Zouk, Hana
Published: (2013)