Synthesis and Characterization of New Etodolac Derivatives with Possible Anti-Inflammatory Activity
A series of Etodolac hydrazone derivatives were synthesized and evaluated for their anti-inflammatory activity by using egg white induced paw edema method. All the synthesized target compounds were characterized by CHN- microanalysis, FT-IR spectroscopy and 1HNMR analysis. The synthesized target com...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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College of Pharmacy University of Baghdad
2019-06-01
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| Series: | Iraqi Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/859 |
| Summary: | A series of Etodolac hydrazone derivatives were synthesized and evaluated for their anti-inflammatory activity by using egg white induced paw edema method. All the synthesized target compounds were characterized by CHN- microanalysis, FT-IR spectroscopy and 1HNMR analysis. The synthesized target compounds (P1-P3) were found to be active in reducing paw edema thickness and their anti-inflammatory effect was comparable to that of the standard (Etodolac).
Keywords: Etodolac hydrazone derivatives, anti-inflammatory, paw edemamethod. |
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| ISSN: | 2521-3512 1683-3597 |