Synthesis and Characterization of New Etodolac Derivatives with Possible Anti-Inflammatory Activity

Synthesis and Characterization of New Etodolac Derivatives with Possible Anti-Inflammatory Activity

A series of Etodolac hydrazone derivatives were synthesized and evaluated for their anti-inflammatory activity by using egg white induced paw edema method. All the synthesized target compounds were characterized by CHN- microanalysis, FT-IR spectroscopy and 1HNMR analysis. The synthesized target com...

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Bibliographic Details
Main Authors: Omeed Muhsin Hassan, Susan Sarsam
Format: Article
Language:English
Published: College of Pharmacy University of Baghdad 2019-06-01
Series:Iraqi Journal of Pharmaceutical Sciences
Subjects:
Etodolac hydrazone derivatives, Anti-inflammatory, Paw edema method
Online Access:http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/859
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spelling doaj-63f56eb248334cb89c911205aca41c5f2020-11-24T21:54:06ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences2521-35121683-35972019-06-0128110711310.31351/vol28iss1pp107-113859Synthesis and Characterization of New Etodolac Derivatives with Possible Anti-Inflammatory ActivityOmeed Muhsin Hassan0Susan SarsamCOLLEGE OF PHARMACY / Baghdad University / MSc.A series of Etodolac hydrazone derivatives were synthesized and evaluated for their anti-inflammatory activity by using egg white induced paw edema method. All the synthesized target compounds were characterized by CHN- microanalysis, FT-IR spectroscopy and 1HNMR analysis. The synthesized target compounds (P1-P3) were found to be active in reducing paw edema thickness and their anti-inflammatory effect was comparable to that of the standard (Etodolac). Keywords: Etodolac hydrazone derivatives, anti-inflammatory, paw edemamethod.http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/859Etodolac hydrazone derivatives, Anti-inflammatory, Paw edema method
collection DOAJ
language English
format Article
sources DOAJ
author Omeed Muhsin Hassan
Susan Sarsam
spellingShingle Omeed Muhsin Hassan
Susan Sarsam
Synthesis and Characterization of New Etodolac Derivatives with Possible Anti-Inflammatory Activity
Iraqi Journal of Pharmaceutical Sciences
Etodolac hydrazone derivatives, Anti-inflammatory, Paw edema method
author_facet Omeed Muhsin Hassan
Susan Sarsam
author_sort Omeed Muhsin Hassan
title Synthesis and Characterization of New Etodolac Derivatives with Possible Anti-Inflammatory Activity
title_short Synthesis and Characterization of New Etodolac Derivatives with Possible Anti-Inflammatory Activity
title_full Synthesis and Characterization of New Etodolac Derivatives with Possible Anti-Inflammatory Activity
title_fullStr Synthesis and Characterization of New Etodolac Derivatives with Possible Anti-Inflammatory Activity
title_full_unstemmed Synthesis and Characterization of New Etodolac Derivatives with Possible Anti-Inflammatory Activity
title_sort synthesis and characterization of new etodolac derivatives with possible anti-inflammatory activity
publisher College of Pharmacy University of Baghdad
series Iraqi Journal of Pharmaceutical Sciences
issn 2521-3512
1683-3597
publishDate 2019-06-01
description A series of Etodolac hydrazone derivatives were synthesized and evaluated for their anti-inflammatory activity by using egg white induced paw edema method. All the synthesized target compounds were characterized by CHN- microanalysis, FT-IR spectroscopy and 1HNMR analysis. The synthesized target compounds (P1-P3) were found to be active in reducing paw edema thickness and their anti-inflammatory effect was comparable to that of the standard (Etodolac). Keywords: Etodolac hydrazone derivatives, anti-inflammatory, paw edemamethod.
topic Etodolac hydrazone derivatives, Anti-inflammatory, Paw edema method
url http://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/859
work_keys_str_mv AT omeedmuhsinhassan synthesisandcharacterizationofnewetodolacderivativeswithpossibleantiinflammatoryactivity
AT susansarsam synthesisandcharacterizationofnewetodolacderivativeswithpossibleantiinflammatoryactivity
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