New Cembranoid Diterpenes from the Cultured Octocoral Nephthea columnaris

New Cembranoid Diterpenes from the Cultured Octocoral Nephthea columnaris

Two new 15-hydroxycembranoid diterpenes, 2β-hydroxy-7β,8α-epoxynephthenol (1) and 2β-hydroxy-11α,12β-epoxynephthenol (2), were isolated from extracts of the octocoral Nephthea columnaris along with a new natural cembrane, epoxynephthenol (3) and a known sterol, nephalsterol A (4). The structures of...

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Main Authors: Ting-Hsi Hsiao, Ching-Hsiao Cheng, Tung-Ying Wu, Mei-Chin Lu, Wu-Fu Chen, Zhi-Hong Wen, Chang-Feng Dai, Yang-Chang Wu, Ping-Jyun Sung
Format: Article
Language:English
Published: MDPI AG 2015-07-01
Series:Molecules
Subjects:
Nephthea columnaris
octocoral
cembrane
nephalsterol
cytotoxicity
Online Access:http://www.mdpi.com/1420-3049/20/7/13205
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spelling doaj-63f7ab79d00346cd83bdd70385d97f912020-11-24T21:31:38ZengMDPI AGMolecules1420-30492015-07-01207132051321510.3390/molecules200713205molecules200713205New Cembranoid Diterpenes from the Cultured Octocoral Nephthea columnarisTing-Hsi Hsiao0Ching-Hsiao Cheng1Tung-Ying Wu2Mei-Chin Lu3Wu-Fu Chen4Zhi-Hong Wen5Chang-Feng Dai6Yang-Chang Wu7Ping-Jyun Sung8Graduate Institute of Marine Biology, National Dong Hwa University, Pingtung 94450, TaiwanDepartment of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanChinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40447, TaiwanGraduate Institute of Marine Biology, National Dong Hwa University, Pingtung 94450, TaiwanDepartment of Neurosurgery, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 83301, TaiwanDepartment of Marine Biotechnology and Resources, Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 80424, TaiwanInstitute of Oceanography, National Taiwan University, Taipei 10617, TaiwanChinese Medicine Research and Development Center, China Medical University Hospital, Taichung 40447, TaiwanGraduate Institute of Marine Biology, National Dong Hwa University, Pingtung 94450, TaiwanTwo new 15-hydroxycembranoid diterpenes, 2β-hydroxy-7β,8α-epoxynephthenol (1) and 2β-hydroxy-11α,12β-epoxynephthenol (2), were isolated from extracts of the octocoral Nephthea columnaris along with a new natural cembrane, epoxynephthenol (3) and a known sterol, nephalsterol A (4). The structures of cembranes 1–3 were elucidated by spectroscopic methods and comparison of the spectroscopic data with those of related analogues. The cytotoxicity of metabolites 1–4 against a panel of tumor cells is also described.http://www.mdpi.com/1420-3049/20/7/13205Nephthea columnarisoctocoralcembranenephalsterolcytotoxicity
collection DOAJ
language English
format Article
sources DOAJ
author Ting-Hsi Hsiao
Ching-Hsiao Cheng
Tung-Ying Wu
Mei-Chin Lu
Wu-Fu Chen
Zhi-Hong Wen
Chang-Feng Dai
Yang-Chang Wu
Ping-Jyun Sung
spellingShingle Ting-Hsi Hsiao
Ching-Hsiao Cheng
Tung-Ying Wu
Mei-Chin Lu
Wu-Fu Chen
Zhi-Hong Wen
Chang-Feng Dai
Yang-Chang Wu
Ping-Jyun Sung
New Cembranoid Diterpenes from the Cultured Octocoral Nephthea columnaris
Molecules
Nephthea columnaris
octocoral
cembrane
nephalsterol
cytotoxicity
author_facet Ting-Hsi Hsiao
Ching-Hsiao Cheng
Tung-Ying Wu
Mei-Chin Lu
Wu-Fu Chen
Zhi-Hong Wen
Chang-Feng Dai
Yang-Chang Wu
Ping-Jyun Sung
author_sort Ting-Hsi Hsiao
title New Cembranoid Diterpenes from the Cultured Octocoral Nephthea columnaris
title_short New Cembranoid Diterpenes from the Cultured Octocoral Nephthea columnaris
title_full New Cembranoid Diterpenes from the Cultured Octocoral Nephthea columnaris
title_fullStr New Cembranoid Diterpenes from the Cultured Octocoral Nephthea columnaris
title_full_unstemmed New Cembranoid Diterpenes from the Cultured Octocoral Nephthea columnaris
title_sort new cembranoid diterpenes from the cultured octocoral nephthea columnaris
publisher MDPI AG
series Molecules
issn 1420-3049
publishDate 2015-07-01
description Two new 15-hydroxycembranoid diterpenes, 2β-hydroxy-7β,8α-epoxynephthenol (1) and 2β-hydroxy-11α,12β-epoxynephthenol (2), were isolated from extracts of the octocoral Nephthea columnaris along with a new natural cembrane, epoxynephthenol (3) and a known sterol, nephalsterol A (4). The structures of cembranes 1–3 were elucidated by spectroscopic methods and comparison of the spectroscopic data with those of related analogues. The cytotoxicity of metabolites 1–4 against a panel of tumor cells is also described.
topic Nephthea columnaris
octocoral
cembrane
nephalsterol
cytotoxicity
url http://www.mdpi.com/1420-3049/20/7/13205
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