Frameshift peptides alter the properties of truncated FUS proteins in ALS-FUS

Frameshift peptides alter the properties of truncated FUS proteins in ALS-FUS

Abstract Mutations in the FUS gene cause a subset of ALS cases (ALS-FUS). The majority of FUS mutations are missense mutations affecting the nuclear localisation signal (NLS) of FUS. In addition, a number of frameshift mutations which result in complete NLS deletion have been described. Patients bea...

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Bibliographic Details
Main Authors: Haiyan An, Camille Rabesahala de Meritens, Vladimir L. Buchman, Tatyana A. Shelkovnikova
Format: Article
Language:English
Published: BMC 2020-05-01
Series:Molecular Brain
Subjects:
Fused in sarcoma
FUS
Amyotrophic lateral sclerosis
ALS
Frameshift mutation
Frameshift peptide
Online Access:http://link.springer.com/article/10.1186/s13041-020-00618-0

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