Estimation of Serum Protein in Oral Potentially Malignant Disorders and Oral Malignancy – A Cross-Sectional Study
Introduction: In carcinogenesis, increased oxidative stress and weakened antioxidant defense produces damage to the macromolecules like proteins. Thus, protein can act as potential biomarker in oral premalignant and malignant lesions. Aim: To determine and compare the levels of serum proteins i...
Main Authors: | , , |
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Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2017-02-01
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Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://jcdr.net/articles/PDF/9254/20815_CE[Ra]_F(Sh)_PF1(NEAK)_PFA(RK)_PF2(P_NZ_PC_RB)_PF3(SH_OM).pdf |
Summary: | Introduction: In carcinogenesis, increased oxidative stress
and weakened antioxidant defense produces damage to the
macromolecules like proteins. Thus, protein can act as potential
biomarker in oral premalignant and malignant lesions.
Aim: To determine and compare the levels of serum proteins
in Oral Submucuous Fibrosis (OSMF), Oral Leukoplakia (OL),
Nicotina Stomatitis (NS), Oral Malignancy (OM) and Healthy
Controls (HC).
Materials and Methods: A total of 250 participants, were
equally divided in five groups i.e., OSMF, OL, NS, OM and HC.
Five ml of blood was collected from antecubital vein from each
participant. The serum was analyzed for total protein, albumin
and globulin levels using EBRA EM 200 semi-quantitive analyzer
with the help of diagnostic kits.
Results: There were total 193 males and 57 females, who were
between 18 to 82 years of age, with a mean of 46.32±13.89
years. The serum protein and globulin levels were significantly
decreased in OSMF, OL and NS and increased in OM as
compared to HC (p<0.001). No statistically significant difference
was found in serum albumin levels between the study groups
(p>0.05).
Conclusion: Serum proteins can be used as diagnostic and
prognostic marker for oral premalignant and malignant lesions. |
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ISSN: | 2249-782X 0973-709X |