Childhood invasive pneumococcal disease caused by non-7-valent pneumococcal vaccine (PCV7) serotypes under partial immunization in Taiwan
Emerging non-7-valent pneumococcal conjugate vaccine (PCV7) serotypes have replaced PCV7 serotypes in childhood invasive pneumococcal disease (IPD). This study was designed to describe the IPD caused by non-PCV7 serotypes under partial PCV7 immunization in Taiwan. Methods: All children <18 years...
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doaj-64048206ef864bb99177a3ecc60b01602020-11-25T00:30:58ZengElsevierJournal of the Formosan Medical Association0929-66462013-09-01112956156810.1016/j.jfma.2013.05.015Childhood invasive pneumococcal disease caused by non-7-valent pneumococcal vaccine (PCV7) serotypes under partial immunization in TaiwanChing-Fen Shen0Shih-Min Wang1Kuan-Hsien Lee2Tzong-Shiann Ho3Ching-Chuan Liu4Department of Pediatrics, College of Medicine, National Cheng Kung University and Hospital, Tainan, TaiwanDepartment of Emergency Medicine, College of Medicine, National Cheng Kung University and Hospital, Tainan, TaiwanDepartment of Pediatrics, College of Medicine, National Cheng Kung University and Hospital, Tainan, TaiwanInstitute of Clinical Medicine, College of Medicine, National Cheng Kung University, Tainan, TaiwanDepartment of Pediatrics, College of Medicine, National Cheng Kung University and Hospital, Tainan, TaiwanEmerging non-7-valent pneumococcal conjugate vaccine (PCV7) serotypes have replaced PCV7 serotypes in childhood invasive pneumococcal disease (IPD). This study was designed to describe the IPD caused by non-PCV7 serotypes under partial PCV7 immunization in Taiwan. Methods: All children <18 years of age diagnosed with IPD at National Cheng Kung University Hospital from 1998 to 2010 were enrolled. Clinical and laboratory information was collected. Pneumococcal isolates were tested for antimicrobial susceptibility and interpreted using Clinical Laboratory Standard Institute guidelines (2008). Serotypes were determined using the capsular swelling method. Results: One hundred and five patients with IPD were identified, including 75 PCV7 and 30 non-PCV7 isolates. Pneumonia (63.3%) was the leading clinical manifestation of non-PCV7 IPDs and 78.9% of pneumonia cases were associated with necrotizing pneumonia or empyema. Children with non-PCV7 IPDs had longer febrile days, required longer intensive care unit stays, and had a higher C-reactive protein level than those with PCV7 IPDs (p < 0.05). Serotype 3 is the most common non-PCV7 serotype (46.7%) and possesses the highest potential for pulmonary complications (p < 0.05, odds ratio: 0.114; 95% confidence interval, 0.013 – 0.973). Conclusion: The changing epidemiology of IPDs following the introduction of PCV7 has been noted. Expanded serotype coverage of the vaccine is warranted.http://www.sciencedirect.com/science/article/pii/S0929664613002027conjugate pneumococcal vaccineepidemiologyinvasive pneumococcal diseaseStreptococcus pneumoniae |
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DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Ching-Fen Shen Shih-Min Wang Kuan-Hsien Lee Tzong-Shiann Ho Ching-Chuan Liu |
spellingShingle |
Ching-Fen Shen Shih-Min Wang Kuan-Hsien Lee Tzong-Shiann Ho Ching-Chuan Liu Childhood invasive pneumococcal disease caused by non-7-valent pneumococcal vaccine (PCV7) serotypes under partial immunization in Taiwan Journal of the Formosan Medical Association conjugate pneumococcal vaccine epidemiology invasive pneumococcal disease Streptococcus pneumoniae |
author_facet |
Ching-Fen Shen Shih-Min Wang Kuan-Hsien Lee Tzong-Shiann Ho Ching-Chuan Liu |
author_sort |
Ching-Fen Shen |
title |
Childhood invasive pneumococcal disease caused by non-7-valent pneumococcal vaccine (PCV7) serotypes under partial immunization in Taiwan |
title_short |
Childhood invasive pneumococcal disease caused by non-7-valent pneumococcal vaccine (PCV7) serotypes under partial immunization in Taiwan |
title_full |
Childhood invasive pneumococcal disease caused by non-7-valent pneumococcal vaccine (PCV7) serotypes under partial immunization in Taiwan |
title_fullStr |
Childhood invasive pneumococcal disease caused by non-7-valent pneumococcal vaccine (PCV7) serotypes under partial immunization in Taiwan |
title_full_unstemmed |
Childhood invasive pneumococcal disease caused by non-7-valent pneumococcal vaccine (PCV7) serotypes under partial immunization in Taiwan |
title_sort |
childhood invasive pneumococcal disease caused by non-7-valent pneumococcal vaccine (pcv7) serotypes under partial immunization in taiwan |
publisher |
Elsevier |
series |
Journal of the Formosan Medical Association |
issn |
0929-6646 |
publishDate |
2013-09-01 |
description |
Emerging non-7-valent pneumococcal conjugate vaccine (PCV7) serotypes have replaced PCV7 serotypes in childhood invasive pneumococcal disease (IPD). This study was designed to describe the IPD caused by non-PCV7 serotypes under partial PCV7 immunization in Taiwan.
Methods: All children <18 years of age diagnosed with IPD at National Cheng Kung University Hospital from 1998 to 2010 were enrolled. Clinical and laboratory information was collected. Pneumococcal isolates were tested for antimicrobial susceptibility and interpreted using Clinical Laboratory Standard Institute guidelines (2008). Serotypes were determined using the capsular swelling method.
Results: One hundred and five patients with IPD were identified, including 75 PCV7 and 30 non-PCV7 isolates. Pneumonia (63.3%) was the leading clinical manifestation of non-PCV7 IPDs and 78.9% of pneumonia cases were associated with necrotizing pneumonia or empyema. Children with non-PCV7 IPDs had longer febrile days, required longer intensive care unit stays, and had a higher C-reactive protein level than those with PCV7 IPDs (p < 0.05). Serotype 3 is the most common non-PCV7 serotype (46.7%) and possesses the highest potential for pulmonary complications (p < 0.05, odds ratio: 0.114; 95% confidence interval, 0.013 – 0.973).
Conclusion: The changing epidemiology of IPDs following the introduction of PCV7 has been noted. Expanded serotype coverage of the vaccine is warranted. |
topic |
conjugate pneumococcal vaccine epidemiology invasive pneumococcal disease Streptococcus pneumoniae |
url |
http://www.sciencedirect.com/science/article/pii/S0929664613002027 |
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