The depletion of Circ‐PRKDC enhances autophagy and apoptosis in T‐cell acute lymphoblastic leukemia via microRNA‐653‐5p/Reelin mediation of the PI3K/AKT/mTOR signaling pathway

The depletion of Circ‐PRKDC enhances autophagy and apoptosis in T‐cell acute lymphoblastic leukemia via microRNA‐653‐5p/Reelin mediation of the PI3K/AKT/mTOR signaling pathway

Abstract A range of circular (Circ) RNAs have been demonstrated to be of therapeutic significance for the treatment of acute lymphoblastic leukemia (ALL). Here, we investigated the mechanisms underlying the action of Circ‐PRKDC and the microRNA‐653‐5p/Reelin (miR‐653‐5p/RELN) axis in T‐cell ALL (T‐A...

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Bibliographic Details
Main Authors: Zhang Ling, Zhi‐Gang Fang, Jie‐Yong Wu, Jia‐Jun Liu
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Kaohsiung Journal of Medical Sciences
Subjects:
circular‐PRKDC
MicroRNA‐653‐5p
PI3K/AKT/mTOR signaling
Reelin
T‐cell acute lymphoblastic leukemia
Online Access:https://doi.org/10.1002/kjm2.12352

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