Hierarchical Oct4 Binding in Concert with Primed Epigenetic Rearrangements during Somatic Cell Reprogramming

Hierarchical Oct4 Binding in Concert with Primed Epigenetic Rearrangements during Somatic Cell Reprogramming

The core pluripotency factor Oct4 plays key roles in somatic cell reprogramming through transcriptional control. Here, we profile Oct4 occupancy, epigenetic changes, and gene expression in reprogramming. We find that Oct4 binds in a hierarchical manner to target sites with primed epigenetic modifica...

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Bibliographic Details
Main Authors: Jun Chen, Xiaolong Chen, Min Li, Xiaoyu Liu, Yawei Gao, Xiaochen Kou, Yanhong Zhao, Weisheng Zheng, Xiaobai Zhang, Yi Huo, Chuan Chen, You Wu, Hong Wang, Cizhong Jiang, Shaorong Gao
Format: Article
Language:English
Published: Elsevier 2016-02-01
Series:Cell Reports
Subjects:
Oct4
reprogramming
histone modification
iPSC
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716000334

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