Different clinical presentations of two renal transplant recipients with coronavirus disease 2019: a case report
Abstract Background The Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome Coronavirus-2 has spread rapidly worldwide and disease spread is currently increasing. Data on the clinical picture of transplant recipients and management of the anti-rejection immunosuppressive...
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doaj-6410509ad9574f2ab59444b36acb12c42020-11-25T03:47:56ZengBMCBMC Infectious Diseases1471-23342020-09-012011810.1186/s12879-020-05434-4Different clinical presentations of two renal transplant recipients with coronavirus disease 2019: a case reportJing Li0Gang Chen1Mingmin Zhang2Shenghao Tu3Chao Chen4Department of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyDepartment of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Background The Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome Coronavirus-2 has spread rapidly worldwide and disease spread is currently increasing. Data on the clinical picture of transplant recipients and management of the anti-rejection immunosuppressive therapy on COVID-19 infection are lacking. Case presentation We report two cases of COVID-19 infection in renal transplant recipients with variable clinical presentations. The first patient presented with mild respiratory symptoms and a stable clinical course. The second patient had more severe clinical characteristics and presented with severe pneumonia and multi-organ failure. Both patients received a combination therapy including antiviral treatment and reduced immunosuppression therapy and finally recovered. Conclusions We report COVID-19 infection in two renal transplant recipients with a favorable outcome but different clinical courses, which may provide a reference value for treating such patients.http://link.springer.com/article/10.1186/s12879-020-05434-4Coronavirus disease 2019Acute respiratory syndrome coronavirus 2Renal transplant recipientsImmunosuppressive therapyCase report |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jing Li Gang Chen Mingmin Zhang Shenghao Tu Chao Chen |
spellingShingle |
Jing Li Gang Chen Mingmin Zhang Shenghao Tu Chao Chen Different clinical presentations of two renal transplant recipients with coronavirus disease 2019: a case report BMC Infectious Diseases Coronavirus disease 2019 Acute respiratory syndrome coronavirus 2 Renal transplant recipients Immunosuppressive therapy Case report |
author_facet |
Jing Li Gang Chen Mingmin Zhang Shenghao Tu Chao Chen |
author_sort |
Jing Li |
title |
Different clinical presentations of two renal transplant recipients with coronavirus disease 2019: a case report |
title_short |
Different clinical presentations of two renal transplant recipients with coronavirus disease 2019: a case report |
title_full |
Different clinical presentations of two renal transplant recipients with coronavirus disease 2019: a case report |
title_fullStr |
Different clinical presentations of two renal transplant recipients with coronavirus disease 2019: a case report |
title_full_unstemmed |
Different clinical presentations of two renal transplant recipients with coronavirus disease 2019: a case report |
title_sort |
different clinical presentations of two renal transplant recipients with coronavirus disease 2019: a case report |
publisher |
BMC |
series |
BMC Infectious Diseases |
issn |
1471-2334 |
publishDate |
2020-09-01 |
description |
Abstract Background The Coronavirus Disease 2019 (COVID-19) caused by severe acute respiratory syndrome Coronavirus-2 has spread rapidly worldwide and disease spread is currently increasing. Data on the clinical picture of transplant recipients and management of the anti-rejection immunosuppressive therapy on COVID-19 infection are lacking. Case presentation We report two cases of COVID-19 infection in renal transplant recipients with variable clinical presentations. The first patient presented with mild respiratory symptoms and a stable clinical course. The second patient had more severe clinical characteristics and presented with severe pneumonia and multi-organ failure. Both patients received a combination therapy including antiviral treatment and reduced immunosuppression therapy and finally recovered. Conclusions We report COVID-19 infection in two renal transplant recipients with a favorable outcome but different clinical courses, which may provide a reference value for treating such patients. |
topic |
Coronavirus disease 2019 Acute respiratory syndrome coronavirus 2 Renal transplant recipients Immunosuppressive therapy Case report |
url |
http://link.springer.com/article/10.1186/s12879-020-05434-4 |
work_keys_str_mv |
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