Treatment of In-Stent Restenosis by Excimer Laser Coronary Atherectomy and Drug-Coated Balloon: Serial Assessment with Optical Coherence Tomography
Objectives. We aimed to compare the results of neointimal modification before drug-coated balloon (DCB) treatment with excimer laser coronary atherectomy (ELCA) plus scoring balloon predilation versus scoring balloon alone in patients presenting with in-stent restenosis (ISR). Background. Treatment...
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Series: | Journal of Interventional Cardiology |
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doaj-6411206c7503469fab32235be7141bb72020-11-25T00:14:41ZengHindawi-WileyJournal of Interventional Cardiology0896-43271540-81832019-01-01201910.1155/2019/65151296515129Treatment of In-Stent Restenosis by Excimer Laser Coronary Atherectomy and Drug-Coated Balloon: Serial Assessment with Optical Coherence TomographyToru Miyazaki0Takashi Ashikaga1Taku Fukushima2Yu Hatano3Taro Sasaoka4Ken Kurihara5Yuichi Ono6Shigeo Shimizu7Kenichiro Otomo8Kenzo Hirao9Department of Cardiovascular Medicine, Ome Municipal General Hospital, Tokyo, JapanDepartment of Cardiology, Musashino Red Cross Hospital, Tokyo, JapanDepartment of Cardiovascular Medicine, National Disaster Medical Center, Tokyo, JapanDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, JapanDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, JapanDepartment of Cardiovascular Medicine, Ome Municipal General Hospital, Tokyo, JapanDepartment of Cardiovascular Medicine, Ome Municipal General Hospital, Tokyo, JapanDepartment of Cardiovascular Medicine, National Disaster Medical Center, Tokyo, JapanDepartment of Cardiovascular Medicine, Ome Municipal General Hospital, Tokyo, JapanDepartment of Cardiovascular Medicine, Tokyo Medical and Dental University, Tokyo, JapanObjectives. We aimed to compare the results of neointimal modification before drug-coated balloon (DCB) treatment with excimer laser coronary atherectomy (ELCA) plus scoring balloon predilation versus scoring balloon alone in patients presenting with in-stent restenosis (ISR). Background. Treatment of ISR with ELCA typically results in superior acute gain by neointima debulking. However, the efficacy of combination therapy of ELCA and DCB remains unknown. Methods. A total of 42 patients (44 ISR lesions) undergoing DCB treatment with ELCA plus scoring balloon (ELCA group, n = 18) or scoring balloon alone (non-ELCA group, n = 24) were evaluated via serial assessment by optical coherence tomography (OCT) performed before, after intervention, and at 6 months. Results. Although there was significantly greater frequency of diffuse restenosis and percent diameter stenosis (%DS) after intervention in the ELCA group, comparable result was shown in %DS, late lumen loss, and binary angiographic restenosis at follow-up. On OCT analysis, a decreased tendency in the minimum lumen area and a significant decrease in the minimum stent area were observed in the ELCA group between 6-month follow-up and after intervention (-0.89 ± 1.36 mm2 vs. -0.09 ± 1.25 mm2, p = 0.05, -0.49 ± 1.48 mm2 vs. 0.28 ± 0.78 mm2, p = 0.03, respectively). The changes in the neointimal area were similar between the groups, and target lesion revascularization showed comparable rates at 1 year (11.1% vs. 11.4%, p = 0.85). Conclusions. Despite greater %DS after intervention, ELCA before DCB had possible benefit for late angiographic and clinical outcome.http://dx.doi.org/10.1155/2019/6515129 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Toru Miyazaki Takashi Ashikaga Taku Fukushima Yu Hatano Taro Sasaoka Ken Kurihara Yuichi Ono Shigeo Shimizu Kenichiro Otomo Kenzo Hirao |
spellingShingle |
Toru Miyazaki Takashi Ashikaga Taku Fukushima Yu Hatano Taro Sasaoka Ken Kurihara Yuichi Ono Shigeo Shimizu Kenichiro Otomo Kenzo Hirao Treatment of In-Stent Restenosis by Excimer Laser Coronary Atherectomy and Drug-Coated Balloon: Serial Assessment with Optical Coherence Tomography Journal of Interventional Cardiology |
author_facet |
Toru Miyazaki Takashi Ashikaga Taku Fukushima Yu Hatano Taro Sasaoka Ken Kurihara Yuichi Ono Shigeo Shimizu Kenichiro Otomo Kenzo Hirao |
author_sort |
Toru Miyazaki |
title |
Treatment of In-Stent Restenosis by Excimer Laser Coronary Atherectomy and Drug-Coated Balloon: Serial Assessment with Optical Coherence Tomography |
title_short |
Treatment of In-Stent Restenosis by Excimer Laser Coronary Atherectomy and Drug-Coated Balloon: Serial Assessment with Optical Coherence Tomography |
title_full |
Treatment of In-Stent Restenosis by Excimer Laser Coronary Atherectomy and Drug-Coated Balloon: Serial Assessment with Optical Coherence Tomography |
title_fullStr |
Treatment of In-Stent Restenosis by Excimer Laser Coronary Atherectomy and Drug-Coated Balloon: Serial Assessment with Optical Coherence Tomography |
title_full_unstemmed |
Treatment of In-Stent Restenosis by Excimer Laser Coronary Atherectomy and Drug-Coated Balloon: Serial Assessment with Optical Coherence Tomography |
title_sort |
treatment of in-stent restenosis by excimer laser coronary atherectomy and drug-coated balloon: serial assessment with optical coherence tomography |
publisher |
Hindawi-Wiley |
series |
Journal of Interventional Cardiology |
issn |
0896-4327 1540-8183 |
publishDate |
2019-01-01 |
description |
Objectives. We aimed to compare the results of neointimal modification before drug-coated balloon (DCB) treatment with excimer laser coronary atherectomy (ELCA) plus scoring balloon predilation versus scoring balloon alone in patients presenting with in-stent restenosis (ISR). Background. Treatment of ISR with ELCA typically results in superior acute gain by neointima debulking. However, the efficacy of combination therapy of ELCA and DCB remains unknown. Methods. A total of 42 patients (44 ISR lesions) undergoing DCB treatment with ELCA plus scoring balloon (ELCA group, n = 18) or scoring balloon alone (non-ELCA group, n = 24) were evaluated via serial assessment by optical coherence tomography (OCT) performed before, after intervention, and at 6 months. Results. Although there was significantly greater frequency of diffuse restenosis and percent diameter stenosis (%DS) after intervention in the ELCA group, comparable result was shown in %DS, late lumen loss, and binary angiographic restenosis at follow-up. On OCT analysis, a decreased tendency in the minimum lumen area and a significant decrease in the minimum stent area were observed in the ELCA group between 6-month follow-up and after intervention (-0.89 ± 1.36 mm2 vs. -0.09 ± 1.25 mm2, p = 0.05, -0.49 ± 1.48 mm2 vs. 0.28 ± 0.78 mm2, p = 0.03, respectively). The changes in the neointimal area were similar between the groups, and target lesion revascularization showed comparable rates at 1 year (11.1% vs. 11.4%, p = 0.85). Conclusions. Despite greater %DS after intervention, ELCA before DCB had possible benefit for late angiographic and clinical outcome. |
url |
http://dx.doi.org/10.1155/2019/6515129 |
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