Determination of the Cytomegalovirus (CMV) infection Role with the Disturbances of Immunoglobulin E (IgE) and Interleukin-33 (IL-33) Concentrations in the Pathogenesis of Asthma and Atherosclerosis in a Sample of Iraqi Patients
Subsequently, the early reactivation or old human cytomegalovirus (HCMV) infection may be interfere with IgE and interleukin-33 (IL-33) levels disturbances throughout the life intervals and act as synergistic factors to play a significant role in the pathogenesis of various diseases; like asthma o...
Main Authors: | , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Journal of Pure and Applied Microbiology
2019-06-01
|
Series: | Journal of Pure and Applied Microbiology |
Subjects: | |
Online Access: | https://microbiologyjournal.org/determination-of-the-cytomegalovirus-cmv-infection-role-with-the-disturbances-of-immunoglobulin-e-ige-and-interleukin-33-il-33-concentrations-in-the-pathogenesis-of-asthma-and-atherosclerosis-in/ |
id |
doaj-641b7d4b163646498491a5276c0669e1 |
---|---|
record_format |
Article |
spelling |
doaj-641b7d4b163646498491a5276c0669e12021-10-02T18:58:29ZengJournal of Pure and Applied MicrobiologyJournal of Pure and Applied Microbiology0973-75102581-690X2019-06-011321003101010.22207/JPAM.13.2.37Determination of the Cytomegalovirus (CMV) infection Role with the Disturbances of Immunoglobulin E (IgE) and Interleukin-33 (IL-33) Concentrations in the Pathogenesis of Asthma and Atherosclerosis in a Sample of Iraqi PatientsJasim Mohammed Muhsin0Sura O. Yousif1Ameer M. Hadi2Ahmed Rahman Rawdhan3Middle Technical University, Health and Medical Technology College, Baghdad, Iraq.Technical Institute, Suwaira, Middle Technical University, Wasit, Iraq.University of Babylon, DNA Research Center, Babylon, Iraq. Shiekh Zayed Hospital, Baghdad, Iraq.Subsequently, the early reactivation or old human cytomegalovirus (HCMV) infection may be interfere with IgE and interleukin-33 (IL-33) levels disturbances throughout the life intervals and act as synergistic factors to play a significant role in the pathogenesis of various diseases; like asthma or coronary heart diseases (CHD). The main subject of the current study was to determine the role of CMV infection onto IgE levels and IL-33 disturbances in the pathogenesis of asthma and atherosclerosis as a case-control study. A total of 175 participants were with a mean age of 38.17 ± 7.51 years [age range: 26–52] years, which were distributed as patients with atherosclerosis (n=50) and asthmatic patients (n=50) as the cases of our study and 75 healthy subjects as a control group. Both groups of asthmatic and atherosclerosis patients show a significant association with the seropositivity of CMV-IgG which was detected in 33 (18.9%) and 30 (17.1%). While, CMV-PP65 Ag which was detected in 26 (14.9%) and 28 (16.0%) respectively (P < 0.0001). High level of abnormal IL-33 was detected in 36 (20.6%) with 45 (25.7%) of abnormal IgE was determined in patients with asthma followed by 26 (14.9%) and 44 (25.1%) for abnormal levels of IL-33 and IgE respectively in patients with atherosclerosis. Furthermore, there was a positive significant association between the seropositivity of CMV-IgG and CMV-PP65 Ag with abnormal IgE and IL-33 levels in the pathogenesis of asthma and atherosclerosis (P < 0.0001), and impact of our study support the hypothesis that previous cytomegalovirus infection or early reactivation with unregulated IL-33 expression or high IgE level play a significant role in the pathogenesis of coronary heart diseases and asthma.https://microbiologyjournal.org/determination-of-the-cytomegalovirus-cmv-infection-role-with-the-disturbances-of-immunoglobulin-e-ige-and-interleukin-33-il-33-concentrations-in-the-pathogenesis-of-asthma-and-atherosclerosis-in/allergycoronary heart diseases (chd)cytomegalovirus (cmv)interleukin (il-33)ige |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jasim Mohammed Muhsin Sura O. Yousif Ameer M. Hadi Ahmed Rahman Rawdhan |
spellingShingle |
Jasim Mohammed Muhsin Sura O. Yousif Ameer M. Hadi Ahmed Rahman Rawdhan Determination of the Cytomegalovirus (CMV) infection Role with the Disturbances of Immunoglobulin E (IgE) and Interleukin-33 (IL-33) Concentrations in the Pathogenesis of Asthma and Atherosclerosis in a Sample of Iraqi Patients Journal of Pure and Applied Microbiology allergy coronary heart diseases (chd) cytomegalovirus (cmv) interleukin (il-33) ige |
author_facet |
Jasim Mohammed Muhsin Sura O. Yousif Ameer M. Hadi Ahmed Rahman Rawdhan |
author_sort |
Jasim Mohammed Muhsin |
title |
Determination of the Cytomegalovirus (CMV) infection Role with the Disturbances of Immunoglobulin E (IgE) and Interleukin-33 (IL-33) Concentrations in the Pathogenesis of Asthma and Atherosclerosis in a Sample of Iraqi Patients |
title_short |
Determination of the Cytomegalovirus (CMV) infection Role with the Disturbances of Immunoglobulin E (IgE) and Interleukin-33 (IL-33) Concentrations in the Pathogenesis of Asthma and Atherosclerosis in a Sample of Iraqi Patients |
title_full |
Determination of the Cytomegalovirus (CMV) infection Role with the Disturbances of Immunoglobulin E (IgE) and Interleukin-33 (IL-33) Concentrations in the Pathogenesis of Asthma and Atherosclerosis in a Sample of Iraqi Patients |
title_fullStr |
Determination of the Cytomegalovirus (CMV) infection Role with the Disturbances of Immunoglobulin E (IgE) and Interleukin-33 (IL-33) Concentrations in the Pathogenesis of Asthma and Atherosclerosis in a Sample of Iraqi Patients |
title_full_unstemmed |
Determination of the Cytomegalovirus (CMV) infection Role with the Disturbances of Immunoglobulin E (IgE) and Interleukin-33 (IL-33) Concentrations in the Pathogenesis of Asthma and Atherosclerosis in a Sample of Iraqi Patients |
title_sort |
determination of the cytomegalovirus (cmv) infection role with the disturbances of immunoglobulin e (ige) and interleukin-33 (il-33) concentrations in the pathogenesis of asthma and atherosclerosis in a sample of iraqi patients |
publisher |
Journal of Pure and Applied Microbiology |
series |
Journal of Pure and Applied Microbiology |
issn |
0973-7510 2581-690X |
publishDate |
2019-06-01 |
description |
Subsequently, the early reactivation or old human cytomegalovirus (HCMV) infection may be interfere
with IgE and interleukin-33 (IL-33) levels disturbances throughout the life intervals and act as synergistic
factors to play a significant role in the pathogenesis of various diseases; like asthma or coronary heart
diseases (CHD). The main subject of the current study was to determine the role of CMV infection onto
IgE levels and IL-33 disturbances in the pathogenesis of asthma and atherosclerosis as a case-control
study. A total of 175 participants were with a mean age of 38.17 ± 7.51 years [age range: 26–52]
years, which were distributed as patients with atherosclerosis (n=50) and asthmatic patients (n=50)
as the cases of our study and 75 healthy subjects as a control group. Both groups of asthmatic and
atherosclerosis patients show a significant association with the seropositivity of CMV-IgG which was
detected in 33 (18.9%) and 30 (17.1%). While, CMV-PP65 Ag which was detected in 26 (14.9%) and
28 (16.0%) respectively (P < 0.0001). High level of abnormal IL-33 was detected in 36 (20.6%) with 45
(25.7%) of abnormal IgE was determined in patients with asthma followed by 26 (14.9%) and 44 (25.1%)
for abnormal levels of IL-33 and IgE respectively in patients with atherosclerosis. Furthermore, there
was a positive significant association between the seropositivity of CMV-IgG and CMV-PP65 Ag with
abnormal IgE and IL-33 levels in the pathogenesis of asthma and atherosclerosis (P < 0.0001), and impact
of our study support the hypothesis that previous cytomegalovirus infection or early reactivation with
unregulated IL-33 expression or high IgE level play a significant role in the pathogenesis of coronary
heart diseases and asthma. |
topic |
allergy coronary heart diseases (chd) cytomegalovirus (cmv) interleukin (il-33) ige |
url |
https://microbiologyjournal.org/determination-of-the-cytomegalovirus-cmv-infection-role-with-the-disturbances-of-immunoglobulin-e-ige-and-interleukin-33-il-33-concentrations-in-the-pathogenesis-of-asthma-and-atherosclerosis-in/ |
work_keys_str_mv |
AT jasimmohammedmuhsin determinationofthecytomegaloviruscmvinfectionrolewiththedisturbancesofimmunoglobulineigeandinterleukin33il33concentrationsinthepathogenesisofasthmaandatherosclerosisinasampleofiraqipatients AT suraoyousif determinationofthecytomegaloviruscmvinfectionrolewiththedisturbancesofimmunoglobulineigeandinterleukin33il33concentrationsinthepathogenesisofasthmaandatherosclerosisinasampleofiraqipatients AT ameermhadi determinationofthecytomegaloviruscmvinfectionrolewiththedisturbancesofimmunoglobulineigeandinterleukin33il33concentrationsinthepathogenesisofasthmaandatherosclerosisinasampleofiraqipatients AT ahmedrahmanrawdhan determinationofthecytomegaloviruscmvinfectionrolewiththedisturbancesofimmunoglobulineigeandinterleukin33il33concentrationsinthepathogenesisofasthmaandatherosclerosisinasampleofiraqipatients |
_version_ |
1716848346291765248 |