Differential regulatory network-based quantification and prioritization of key genes underlying cancer drug resistance based on time-course RNA-seq data.

Differential regulatory network-based quantification and prioritization of key genes underlying cancer drug resistance based on time-course RNA-seq data.

Drug resistance is a major cause for the failure of cancer chemotherapy or targeted therapy. However, the molecular regulatory mechanisms controlling the dynamic evolvement of drug resistance remain poorly understood. Thus, it is important to develop methods for identifying key gene regulatory mecha...

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Bibliographic Details
Main Authors:	Jiajun Zhang, Wenbo Zhu, Qianliang Wang, Jiayu Gu, L Frank Huang, Xiaoqiang Sun
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2019-11-01
Series:	PLoS Computational Biology
Online Access:	https://doi.org/10.1371/journal.pcbi.1007435

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