BRCA1-regulated RRM2 expression protects glioblastoma cells from endogenous replication stress and promotes tumorigenicity
BRCA1 loss can result in collapse of replication forks into DNA double strand breaks that can contribute to malignant transformation. Here, the authors find that BRCA1 promotes the expression of RRM2 protecting glioblastoma cells from replication stress, DNA damage and apoptosis.
Bibliographic Details
| Main Authors: |
Rikke D. Rasmussen,
Madhavsai K. Gajjar,
Lucie Tuckova,
Kamilla E. Jensen,
Apolinar Maya-Mendoza,
Camilla B. Holst,
Kjeld Møllgaard,
Jane S. Rasmussen,
Jannick Brennum,
Jiri Bartek,
Martin Syrucek,
Eva Sedlakova,
Klaus K. Andersen,
Marie H. Frederiksen,
Petra Hamerlik |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Publishing Group
2016-11-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/ncomms13398
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