Circulating Monocyte Chemoattractant Protein-1 Levels and Lumbar Bone Mineral Density in Korean Women

• Main Author: Seong-Kyu Lee
• Format: Article
• Language: English
• Published: Korean Society for the Study of Obesity 2017-12-01
• Series: Journal of Obesity & Metabolic Syndrome
• Subjects: Monocyte chemoattractant protein-1; Bone density; Women
• Online Access: https://doi.org/10.7570/jomes.2017.26.4.287

Background : Monocyte chemoattractant protein-1 (MCP-1) is expressed in adipose tissue, macrophages, endothelial cells, and osteoblasts by parathyroid hormone administration. Circulating MCP-1 levels are positively correlated with the degree of obesity. However, whether circulating MCP-1 affects bone metabolism is unclear. Therefore, in this study, the association between circulating MCP-1 levels and lumbar bone mineral density (BMD) based on menopausal status was assessed. Methods : We recruited 109 premenopausal and 46 postmenopausal Korean women and examined the association between circulating MCP-1 concentrations and various parameters including lumbar BMD based on menopausal status. Results : A significant increase in body weight, abdominal circumference, body mass index, and MCP-1 levels (from 245.9±73.5 to 336.5±101.7 pg/mL) and significant decrease (from 0.992±0.114 to 0.772±0.113 g/cm²) in lumbar BMD were observed after menopause. However, circulating MCP-1 levels were not correlated with any parameters including lumbar BMD in premenopausal or postmenopausal women. Conclusion : Circulating MCP-1 levels were not correlated with lumbar BMD regardless of menopausal status.