Hyperuricaemia – A Potential Indicator to Diagnose the Risk of Essential Hypertension
Introduction: Hypertension has turned out to be the major cause of morbidity among the life style diseases. Studies in human and animal models have documented an independent association of hyperuricaemia with early hypertension. Hyperuricaemia is a modifiable and treatable risk factor, which mig...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
JCDR Research and Publications Private Limited
2016-03-01
|
Series: | Journal of Clinical and Diagnostic Research |
Subjects: | |
Online Access: | https://jcdr.net/articles/PDF/7394/17747_CE[Ra1]_F(GH)_PF1(Ro_Om)_PFA(AK)_PF2(PAG).pdf |
Summary: | Introduction: Hypertension has turned out to be the major cause
of morbidity among the life style diseases. Studies in human and
animal models have documented an independent association
of hyperuricaemia with early hypertension. Hyperuricaemia is
a modifiable and treatable risk factor, which might reduce the
incidence of Essential Hypertension (EHT).
Aim: Hence, the present study was designed to find out the
association between hyperuricaemia and EHT in the population
of Southern Rajasthan as there is a dearth of literature on Indian
scenario especially in Rajasthan.
Materials and Methods: A cross-sectional, case control study
was carried out in the Department of Physiology among 125
subjects; aged 20-50 years of both sexes, which were chosen
randomly from Medicine OPD and healthy volunteers. The
subjects were broadly divided into two groups (A & B); group
A comprised of newly diagnosed cases of EHT (n=75) and
group B had healthy normotensive controls (n=50). S. Uric Acid
(SUA), Serum creatinine and fasting blood glucose levels were
estimated by using the respective kit methods on semi autoanalyser in both groups. S. creatinine and fasting blood glucose
levels were estimated to exclude renal disorder and diabetes
mellitus respectively. The data was analysed by student t-test,
chi-square test and Odds Ratio.
Results: The mean SUA level in group A was significantly
higher than group B (6.56 ± 0.76, 4.91 ± 0.97 mg/dl, p<0.001
respectively). 37.33% of patients had hyperuricaemia in group
A as compared to 14% in group B (p<0.01, OR=3.66) indicating
that a hyperuricaemic individual has 3.66 times more risk of
developing EHT as compared to the one with lower value of
SUA.
Conclusion: The mean SUA level and the frequency of
hyperuricaemia was significantly higher in newly diagnosed
cases of EHT as compared to healthy controls. Hence, SUA
could be useful as a potential indicator for early risk detection
of development of EHT. |
---|---|
ISSN: | 2249-782X 0973-709X |