Hyperuricaemia – A Potential Indicator to Diagnose the Risk of Essential Hypertension
Introduction: Hypertension has turned out to be the major cause of morbidity among the life style diseases. Studies in human and animal models have documented an independent association of hyperuricaemia with early hypertension. Hyperuricaemia is a modifiable and treatable risk factor, which mig...
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doaj-64523f0f3333413fba5c206214a4f2c52020-11-25T03:14:15ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2016-03-01103CC01CC0310.7860/JCDR/2016/17747.7394Hyperuricaemia – A Potential Indicator to Diagnose the Risk of Essential HypertensionChanchal Shrivastav0Manjinder Kaur1M.L. Suhalka2Suman Sharma3Abhijit Basu4Assistant Professor, Department of Physiology, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India.Professor, Department of Physiology, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India.Professor and Head, Department of Physiology, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India.Assistant Professor, Department of Physiology, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India.Professor, Department of General Medicine, Geetanjali Medical College and Hospital, Udaipur, Rajasthan, India.Introduction: Hypertension has turned out to be the major cause of morbidity among the life style diseases. Studies in human and animal models have documented an independent association of hyperuricaemia with early hypertension. Hyperuricaemia is a modifiable and treatable risk factor, which might reduce the incidence of Essential Hypertension (EHT). Aim: Hence, the present study was designed to find out the association between hyperuricaemia and EHT in the population of Southern Rajasthan as there is a dearth of literature on Indian scenario especially in Rajasthan. Materials and Methods: A cross-sectional, case control study was carried out in the Department of Physiology among 125 subjects; aged 20-50 years of both sexes, which were chosen randomly from Medicine OPD and healthy volunteers. The subjects were broadly divided into two groups (A & B); group A comprised of newly diagnosed cases of EHT (n=75) and group B had healthy normotensive controls (n=50). S. Uric Acid (SUA), Serum creatinine and fasting blood glucose levels were estimated by using the respective kit methods on semi autoanalyser in both groups. S. creatinine and fasting blood glucose levels were estimated to exclude renal disorder and diabetes mellitus respectively. The data was analysed by student t-test, chi-square test and Odds Ratio. Results: The mean SUA level in group A was significantly higher than group B (6.56 ± 0.76, 4.91 ± 0.97 mg/dl, p<0.001 respectively). 37.33% of patients had hyperuricaemia in group A as compared to 14% in group B (p<0.01, OR=3.66) indicating that a hyperuricaemic individual has 3.66 times more risk of developing EHT as compared to the one with lower value of SUA. Conclusion: The mean SUA level and the frequency of hyperuricaemia was significantly higher in newly diagnosed cases of EHT as compared to healthy controls. Hence, SUA could be useful as a potential indicator for early risk detection of development of EHT.https://jcdr.net/articles/PDF/7394/17747_CE[Ra1]_F(GH)_PF1(Ro_Om)_PFA(AK)_PF2(PAG).pdfprimary hypertensionpreclinical hyperuricaemiaserum uric acidsouthern rajasthan |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Chanchal Shrivastav Manjinder Kaur M.L. Suhalka Suman Sharma Abhijit Basu |
spellingShingle |
Chanchal Shrivastav Manjinder Kaur M.L. Suhalka Suman Sharma Abhijit Basu Hyperuricaemia – A Potential Indicator to Diagnose the Risk of Essential Hypertension Journal of Clinical and Diagnostic Research primary hypertension preclinical hyperuricaemia serum uric acid southern rajasthan |
author_facet |
Chanchal Shrivastav Manjinder Kaur M.L. Suhalka Suman Sharma Abhijit Basu |
author_sort |
Chanchal Shrivastav |
title |
Hyperuricaemia – A Potential Indicator to Diagnose the Risk of Essential Hypertension |
title_short |
Hyperuricaemia – A Potential Indicator to Diagnose the Risk of Essential Hypertension |
title_full |
Hyperuricaemia – A Potential Indicator to Diagnose the Risk of Essential Hypertension |
title_fullStr |
Hyperuricaemia – A Potential Indicator to Diagnose the Risk of Essential Hypertension |
title_full_unstemmed |
Hyperuricaemia – A Potential Indicator to Diagnose the Risk of Essential Hypertension |
title_sort |
hyperuricaemia – a potential indicator to diagnose the risk of essential hypertension |
publisher |
JCDR Research and Publications Private Limited |
series |
Journal of Clinical and Diagnostic Research |
issn |
2249-782X 0973-709X |
publishDate |
2016-03-01 |
description |
Introduction: Hypertension has turned out to be the major cause
of morbidity among the life style diseases. Studies in human and
animal models have documented an independent association
of hyperuricaemia with early hypertension. Hyperuricaemia is
a modifiable and treatable risk factor, which might reduce the
incidence of Essential Hypertension (EHT).
Aim: Hence, the present study was designed to find out the
association between hyperuricaemia and EHT in the population
of Southern Rajasthan as there is a dearth of literature on Indian
scenario especially in Rajasthan.
Materials and Methods: A cross-sectional, case control study
was carried out in the Department of Physiology among 125
subjects; aged 20-50 years of both sexes, which were chosen
randomly from Medicine OPD and healthy volunteers. The
subjects were broadly divided into two groups (A & B); group
A comprised of newly diagnosed cases of EHT (n=75) and
group B had healthy normotensive controls (n=50). S. Uric Acid
(SUA), Serum creatinine and fasting blood glucose levels were
estimated by using the respective kit methods on semi autoanalyser in both groups. S. creatinine and fasting blood glucose
levels were estimated to exclude renal disorder and diabetes
mellitus respectively. The data was analysed by student t-test,
chi-square test and Odds Ratio.
Results: The mean SUA level in group A was significantly
higher than group B (6.56 ± 0.76, 4.91 ± 0.97 mg/dl, p<0.001
respectively). 37.33% of patients had hyperuricaemia in group
A as compared to 14% in group B (p<0.01, OR=3.66) indicating
that a hyperuricaemic individual has 3.66 times more risk of
developing EHT as compared to the one with lower value of
SUA.
Conclusion: The mean SUA level and the frequency of
hyperuricaemia was significantly higher in newly diagnosed
cases of EHT as compared to healthy controls. Hence, SUA
could be useful as a potential indicator for early risk detection
of development of EHT. |
topic |
primary hypertension preclinical hyperuricaemia serum uric acid southern rajasthan |
url |
https://jcdr.net/articles/PDF/7394/17747_CE[Ra1]_F(GH)_PF1(Ro_Om)_PFA(AK)_PF2(PAG).pdf |
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