Cancer Cell Acid Adaptation Gene Expression Response Is Correlated to Tumor-Specific Tissue Expression Profiles and Patient Survival

Cancer Cell Acid Adaptation Gene Expression Response Is Correlated to Tumor-Specific Tissue Expression Profiles and Patient Survival

The acidic pH of the tumor microenvironment plays a critical role in driving cancer development toward a more aggressive phenotype, but the underlying mechanisms are unclear. To this end, phenotypic and genotypic changes induced by adaptation of cancer cells to chronic acidosis have been studied. Ho...

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Bibliographic Details
Main Authors: Jiayi Yao, Dominika Czaplinska, Renata Ialchina, Julie Schnipper, Bin Liu, Albin Sandelin, Stine Falsig Pedersen
Format: Article
Language:English
Published: MDPI AG 2020-08-01
Series:Cancers
Subjects:
RNA sequencing
tumor microenvironment
chronic acidosis
survival analysis
acid adaptation
medical transcriptomics
Online Access:https://www.mdpi.com/2072-6694/12/8/2183

Internet

https://www.mdpi.com/2072-6694/12/8/2183

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