Metastatic Phosphatase PRL-3 Induces Ovarian Cancer Stem Cell Sub-population through Phosphatase-Independent Deacetylation Modulations

Metastatic Phosphatase PRL-3 Induces Ovarian Cancer Stem Cell Sub-population through Phosphatase-Independent Deacetylation Modulations

Summary: Cancer stem cells (CSCs) are responsible for tumor initiation, chemoresistance, metastasis, and relapse, but the underlying molecular origin of CSCs remains elusive. Here we identified that metastatic phosphatase of regenerating liver 3 (PRL-3) transcriptionally upregulates SOX2 in the expa...

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Bibliographic Details
Main Authors: Mingming Zhang, Yanli Wei, Yanbin Liu, Wen Guan, Xiaomei Zhang, Jianqiu Kong, Hui Li, Shulan Yang, Haihe Wang
Format: Article
Language:English
Published: Elsevier 2020-01-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004219305115

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