EXPERIENCE IN LOCAL IMMUNOCORRECTION IN TREATMENT OF CHRONIC WOUNDS

• Main Authors: M. A. Khalilov, I. A. Snimchsikova
• Format: Article
• Language: Russian
• Published: SPb RAACI 2014-07-01
• Series: Medicinskaâ Immunologiâ
• Subjects: wound process; chronic wounds; local immunocorrection; myelopid; nо therapy.
• Online Access: https://www.mimmun.ru/mimmun/article/view/96

In this article, we present results of local treatment of purulent wounds caused by various agents, in 232 patients, using local immunocorrection techniques combined with therapeutic application of nitrogen monoxide (NO). A series of immunological, cytological, microbiological researches have been carried out, showing a direct antibacterial effect of myelopid has been defined, and appropriate criteria have been developed for scoring intensity of inflammation affecting soft tissues. A justification for combined therapy with NО and myelopid has been obtained, and a method of local treatment of wound infections has been offered and patented. Basing on these experimental and clinical studies, as well as dynamic indices of wound process, we have shown a benefit from local immunocorrection by means of combined NО/myelopid treatment for complex therapy of purulent wounds.