Hawthorn ethanolic extracts with triterpenoids and flavonoids exert hepatoprotective effects and suppress the hypercholesterolemia-induced oxidative stress in rats

• Main Authors: Ali Rezaei-Golmisheh, Hassan Malekinejad, Siamak Asri-Rezaei, Amir Abbas Farshid, Peyman Akbari
• Format: Article
• Language: English
• Published: Mashhad University of Medical Sciences 2015-07-01
• Series: Iranian Journal of Basic Medical Sciences
• Subjects: Antioxidant; Bioactive compounds; Flavonoids; Hepatoprotective Triterpenoids
• Online Access: http://ijbms.mums.ac.ir/pdf_4652_63874c091492c0bf19cf4413ec404803.html

Objective(s):The current study was aimed to determine the bioactive constituents and biological effects of the Crataegus monogyna ethanolic extracts from bark, leaves and berries on hypercholesterolemia. Materials and Methods: Oleanolic acid, ursolic acid, quercetin and lupeol concentrations were quantified by HPLC. Total phenol content and radical scavenging activity of extracts were also measured. The hypocholesterolemic, antioxidant, and hepatoprotective effects of the extracts were examined in hypercholesterolemic rats and compared with orlistat. Results: The highest phenol content, oleanolic acid, quercetin and lupeol levels and free radical scavenging potency were found in the bark extract, and the highest ursolic acid level was found in the berries extract. Orlistat and extracts significantly (P