Impact of chronic and acute academic stress on lymphocyte subsets and monocyte function.
This study investigated the effects of a temporally confined naturalistic stressor (academic stress) on immune functions. Furthermore, moderating influences of a number of psychological variables were assessed. Five blood samples were obtained from 20 students during an observation period of 8 weeks...
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doaj-647175e0c2a440bfaebb5dec5a0e80632020-11-25T00:24:19ZengPublic Library of Science (PLoS)PLoS ONE1932-62032017-01-011211e018810810.1371/journal.pone.0188108Impact of chronic and acute academic stress on lymphocyte subsets and monocyte function.Viktoriya MaydychMaren ClausNicole DychusMelanie EbelJürgen DamaschkeStefan DiestelOliver T WolfThomas KleinsorgeCarsten WatzlThis study investigated the effects of a temporally confined naturalistic stressor (academic stress) on immune functions. Furthermore, moderating influences of a number of psychological variables were assessed. Five blood samples were obtained from 20 students during an observation period of 8 weeks, starting 4.5 weeks before an exam period up to 1 week following the last exam. The analysis of 45 immune parameters revealed several time-dependent changes attributable to examination stress. We observed a reduction in the absolute numbers of natural killer (NK) cells and monocytes in peripheral blood and a shift towards more immature and naïve cells within NK and T cell populations. In addition, IL-6 and TNF-α production by LPS-stimulated monocytes was increased. Psychological variables were grouped by means of factor analyses into two factors. One factor, which was interpreted as an indication of chronic stress, moderated the relationships between academic stress and percentages of mature CD57+ NK cells. This chronic stress factor was also associated with an increase in memory and a decrease in naïve CD8 T cells and increased serum levels of IL-17. The present study identifies important potential psychological mediators of stress-induced changes in specific immunological parameters.http://europepmc.org/articles/PMC5690587?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Viktoriya Maydych Maren Claus Nicole Dychus Melanie Ebel Jürgen Damaschke Stefan Diestel Oliver T Wolf Thomas Kleinsorge Carsten Watzl |
spellingShingle |
Viktoriya Maydych Maren Claus Nicole Dychus Melanie Ebel Jürgen Damaschke Stefan Diestel Oliver T Wolf Thomas Kleinsorge Carsten Watzl Impact of chronic and acute academic stress on lymphocyte subsets and monocyte function. PLoS ONE |
author_facet |
Viktoriya Maydych Maren Claus Nicole Dychus Melanie Ebel Jürgen Damaschke Stefan Diestel Oliver T Wolf Thomas Kleinsorge Carsten Watzl |
author_sort |
Viktoriya Maydych |
title |
Impact of chronic and acute academic stress on lymphocyte subsets and monocyte function. |
title_short |
Impact of chronic and acute academic stress on lymphocyte subsets and monocyte function. |
title_full |
Impact of chronic and acute academic stress on lymphocyte subsets and monocyte function. |
title_fullStr |
Impact of chronic and acute academic stress on lymphocyte subsets and monocyte function. |
title_full_unstemmed |
Impact of chronic and acute academic stress on lymphocyte subsets and monocyte function. |
title_sort |
impact of chronic and acute academic stress on lymphocyte subsets and monocyte function. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2017-01-01 |
description |
This study investigated the effects of a temporally confined naturalistic stressor (academic stress) on immune functions. Furthermore, moderating influences of a number of psychological variables were assessed. Five blood samples were obtained from 20 students during an observation period of 8 weeks, starting 4.5 weeks before an exam period up to 1 week following the last exam. The analysis of 45 immune parameters revealed several time-dependent changes attributable to examination stress. We observed a reduction in the absolute numbers of natural killer (NK) cells and monocytes in peripheral blood and a shift towards more immature and naïve cells within NK and T cell populations. In addition, IL-6 and TNF-α production by LPS-stimulated monocytes was increased. Psychological variables were grouped by means of factor analyses into two factors. One factor, which was interpreted as an indication of chronic stress, moderated the relationships between academic stress and percentages of mature CD57+ NK cells. This chronic stress factor was also associated with an increase in memory and a decrease in naïve CD8 T cells and increased serum levels of IL-17. The present study identifies important potential psychological mediators of stress-induced changes in specific immunological parameters. |
url |
http://europepmc.org/articles/PMC5690587?pdf=render |
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