Anti-CXCL4 Antibody Reactivity Is Present in Systemic Sclerosis (SSc) and Correlates with the SSc Type I Interferon Signature

Anti-CXCL4 Antibody Reactivity Is Present in Systemic Sclerosis (SSc) and Correlates with the SSc Type I Interferon Signature

Systemic sclerosis (SSc) is characterized by skin/internal organ fibrosis, vasculopathy and autoimmunity. Chemokine (C-X-C motif) ligand 4 (CXCL4) is an SSc biomarker, predicting unfavorable prognosis and lung fibrosis. CXCL4 binds DNA/RNA and favors interferon (IFN)-α production by plasmacytoid den...

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Bibliographic Details
Main Authors: Roberto Lande, Anna Mennella, Raffaella Palazzo, Immacolata Pietraforte, Katia Stefanantoni, Nicoletta Iannace, Alessia Butera, Monica Boirivant, Roberta Pica, Curdin Conrad, Carlo Chizzolini, Valeria Riccieri, Loredana Frasca
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:International Journal of Molecular Sciences
Subjects:
autoantibodies
CXCL4
type I interferon
lung fibrosis
innate immunity
adaptive immunity
Online Access:https://www.mdpi.com/1422-0067/21/14/5102

Internet

https://www.mdpi.com/1422-0067/21/14/5102

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