Constituintes químicos das cascas do caule de Vochysia thyrsoidea Pohl. (Vochysiaceae) e avaliação das atividades citotóxica e inibitória frente as catepsinas B e K

• Main Authors: Lorena Ramos Freitas de Sousa, Jame's A. da Silva, Paulo Cezar Vieira, Maísa Borges Costa, Mirley Luciene dos Santos, Aline Borba Sbardelotto, Cláudia do Ó Pessoa, Manoel Odorico de Moraes, Antônio Carlos Severo Menezes
• Format: Article
• Language: English
• Published: Sociedade Brasileira de Química 2014-04-01
• Series: Química Nova
• Subjects: Vochysia thyrsoidea; Vochysiaceae; catechin derivatives
• Online Access: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-40422014000200016&lng=en&tlng=en
• ISSN: 1678-7064

A new flavonoid, catechin-3-O-(3"-O-trans-cinnamoyl)-α-rhamnopyranoside, along with known compounds, catechin-3-O-α-rhamnopyranoside, 3-oxo-urs-12-en-28-oic acid, 2,4,6-trimethoxybenzoic acid, 2-butyl-D-fructofuranoside and 1-butyl-D-fructofuranoside, has been isolated from the stem bark of V. thyrsoidea. These compounds were assayed for inhibition of protease activity (cathepsins B and K) and against cancer cell lines. Catechin-3-O-(3"-O-trans-cinnamoyl)-α-rhamnopyranoside showed moderate inhibitory activity (IC50 = 62.02 µM) against cathepsin B while 2-butyl-D-fructofuranoside was the most potent against a strain of CNS (SF-295) and human leukemia (HL-60) with IC50 = 36.80 µM and IC50 = 25.37 µM, respectively.