Evaluation Procoagulant Activity and Mechanism of Astragalin
Astragalin, isolated from flowers of <i>Rosa chinensis</i> Jacq., is a kind of flavonoid, with anti-inflammatory, antioxidant, antiviral, analgesic, antibacterial, antiallergic, and antihepatotoxic effects. However, no studieson the procoagulant effect of astragalin have been reported. T...
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doaj-64892a224dc6446caf13569c8b34bc1c2020-11-25T01:49:14ZengMDPI AGMolecules1420-30492020-01-0125117710.3390/molecules25010177molecules25010177Evaluation Procoagulant Activity and Mechanism of AstragalinChangqin Li0Miyun Hu1Shengjun Jiang2Zhenhua Liang3Jinmei Wang4Zhenhua Liu5Hui-Min David Wang6Wenyi Kang7National R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, ChinaNational R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, ChinaNational R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, ChinaNational R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, ChinaNational R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, ChinaNational R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, ChinaGraduate Institute of Biomedical Engineering, National Chung Hsing University, Taichung City 402, TaiwanNational R & D Center for Edible Fungus Processing Technology, Henan University, Kaifeng 475004, ChinaAstragalin, isolated from flowers of <i>Rosa chinensis</i> Jacq., is a kind of flavonoid, with anti-inflammatory, antioxidant, antiviral, analgesic, antibacterial, antiallergic, and antihepatotoxic effects. However, no studieson the procoagulant effect of astragalin have been reported. This study aimed to investigate the procoagulant activity of astragalin and its mechanism. Its procoagulant effect was investigated by activated partial thromboplastin time (APTT), thrombin time (TT), prothrombin time (PT), and fibrinogen (FIB) in vitro, and a rat model established by heparin sodium was used to evaluate the mechanism for the procoagulant effect in vivo. The results showed that astragalin had good procoagulant effects compared with the control group in vitro. Compared with the model group in vivo, astragalin could shorten the coagulation time and significantly increase the number of platelets. Meanwhile, astragalin could significantly reduce the effectual time of PT and APTT and increase the content of FIB. The contents of 6-keto-PGF<sub>1<i>α</i></sub> and eNOS significantly decreased. Astragalin could increase whole blood viscosity (WBV), plasma viscosity (PV), erythrocyte sedimentation rate (ESR) and packedcell volume (PCV). All of the above revealed that astragalin had good procoagulant effects by promoting the intrinsic and extrinsic coagulation system.https://www.mdpi.com/1420-3049/25/1/177<i>rose chinensis</i> jacqastragalinprocoagulant effect |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Changqin Li Miyun Hu Shengjun Jiang Zhenhua Liang Jinmei Wang Zhenhua Liu Hui-Min David Wang Wenyi Kang |
spellingShingle |
Changqin Li Miyun Hu Shengjun Jiang Zhenhua Liang Jinmei Wang Zhenhua Liu Hui-Min David Wang Wenyi Kang Evaluation Procoagulant Activity and Mechanism of Astragalin Molecules <i>rose chinensis</i> jacq astragalin procoagulant effect |
author_facet |
Changqin Li Miyun Hu Shengjun Jiang Zhenhua Liang Jinmei Wang Zhenhua Liu Hui-Min David Wang Wenyi Kang |
author_sort |
Changqin Li |
title |
Evaluation Procoagulant Activity and Mechanism of Astragalin |
title_short |
Evaluation Procoagulant Activity and Mechanism of Astragalin |
title_full |
Evaluation Procoagulant Activity and Mechanism of Astragalin |
title_fullStr |
Evaluation Procoagulant Activity and Mechanism of Astragalin |
title_full_unstemmed |
Evaluation Procoagulant Activity and Mechanism of Astragalin |
title_sort |
evaluation procoagulant activity and mechanism of astragalin |
publisher |
MDPI AG |
series |
Molecules |
issn |
1420-3049 |
publishDate |
2020-01-01 |
description |
Astragalin, isolated from flowers of <i>Rosa chinensis</i> Jacq., is a kind of flavonoid, with anti-inflammatory, antioxidant, antiviral, analgesic, antibacterial, antiallergic, and antihepatotoxic effects. However, no studieson the procoagulant effect of astragalin have been reported. This study aimed to investigate the procoagulant activity of astragalin and its mechanism. Its procoagulant effect was investigated by activated partial thromboplastin time (APTT), thrombin time (TT), prothrombin time (PT), and fibrinogen (FIB) in vitro, and a rat model established by heparin sodium was used to evaluate the mechanism for the procoagulant effect in vivo. The results showed that astragalin had good procoagulant effects compared with the control group in vitro. Compared with the model group in vivo, astragalin could shorten the coagulation time and significantly increase the number of platelets. Meanwhile, astragalin could significantly reduce the effectual time of PT and APTT and increase the content of FIB. The contents of 6-keto-PGF<sub>1<i>α</i></sub> and eNOS significantly decreased. Astragalin could increase whole blood viscosity (WBV), plasma viscosity (PV), erythrocyte sedimentation rate (ESR) and packedcell volume (PCV). All of the above revealed that astragalin had good procoagulant effects by promoting the intrinsic and extrinsic coagulation system. |
topic |
<i>rose chinensis</i> jacq astragalin procoagulant effect |
url |
https://www.mdpi.com/1420-3049/25/1/177 |
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