Interferon-Gamma-Mediated Osteoimmunology
Osteoimmunology is the interdiscipline that focuses on the relationship between the skeletal and immune systems. They are interconnected by shared signal pathways and cytokines. Interferon-gamma (IFN-γ) plays important roles in immune responses and bone metabolism. IFN-γ enhances macrophage activati...
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Frontiers Media S.A.
2018-06-01
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doaj-648c65b19f8a4f09a64cdde989046aad2020-11-24T21:20:12ZengFrontiers Media S.A.Frontiers in Immunology1664-32242018-06-01910.3389/fimmu.2018.01508368382Interferon-Gamma-Mediated OsteoimmunologyMengjia TangLi TianGuojing LuoXijie YuOsteoimmunology is the interdiscipline that focuses on the relationship between the skeletal and immune systems. They are interconnected by shared signal pathways and cytokines. Interferon-gamma (IFN-γ) plays important roles in immune responses and bone metabolism. IFN-γ enhances macrophage activation and antigen presentation. It regulates antiviral and antibacterial immunity as well as signal transduction. IFN-γ can promote osteoblast differentiation and inhibit bone marrow adipocyte formation. IFN-γ plays dual role in osteoclasts depending on its stage. Furthermore, IFN-γ is an important pathogenetic factor in some immune-mediated bone diseases including rheumatoid arthritis, postmenopausal osteoporosis, and acquired immunodeficiency syndrome. This review will discuss the contradictory findings of IFN-γ in osteoimmunology and its clinical application potential.https://www.frontiersin.org/article/10.3389/fimmu.2018.01508/fullosteoimmunologyinterferon-gammaosteoclastsosteoblastsrheumatoid arthritispostmenopausal osteoporosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mengjia Tang Li Tian Guojing Luo Xijie Yu |
spellingShingle |
Mengjia Tang Li Tian Guojing Luo Xijie Yu Interferon-Gamma-Mediated Osteoimmunology Frontiers in Immunology osteoimmunology interferon-gamma osteoclasts osteoblasts rheumatoid arthritis postmenopausal osteoporosis |
author_facet |
Mengjia Tang Li Tian Guojing Luo Xijie Yu |
author_sort |
Mengjia Tang |
title |
Interferon-Gamma-Mediated Osteoimmunology |
title_short |
Interferon-Gamma-Mediated Osteoimmunology |
title_full |
Interferon-Gamma-Mediated Osteoimmunology |
title_fullStr |
Interferon-Gamma-Mediated Osteoimmunology |
title_full_unstemmed |
Interferon-Gamma-Mediated Osteoimmunology |
title_sort |
interferon-gamma-mediated osteoimmunology |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Immunology |
issn |
1664-3224 |
publishDate |
2018-06-01 |
description |
Osteoimmunology is the interdiscipline that focuses on the relationship between the skeletal and immune systems. They are interconnected by shared signal pathways and cytokines. Interferon-gamma (IFN-γ) plays important roles in immune responses and bone metabolism. IFN-γ enhances macrophage activation and antigen presentation. It regulates antiviral and antibacterial immunity as well as signal transduction. IFN-γ can promote osteoblast differentiation and inhibit bone marrow adipocyte formation. IFN-γ plays dual role in osteoclasts depending on its stage. Furthermore, IFN-γ is an important pathogenetic factor in some immune-mediated bone diseases including rheumatoid arthritis, postmenopausal osteoporosis, and acquired immunodeficiency syndrome. This review will discuss the contradictory findings of IFN-γ in osteoimmunology and its clinical application potential. |
topic |
osteoimmunology interferon-gamma osteoclasts osteoblasts rheumatoid arthritis postmenopausal osteoporosis |
url |
https://www.frontiersin.org/article/10.3389/fimmu.2018.01508/full |
work_keys_str_mv |
AT mengjiatang interferongammamediatedosteoimmunology AT litian interferongammamediatedosteoimmunology AT guojingluo interferongammamediatedosteoimmunology AT xijieyu interferongammamediatedosteoimmunology |
_version_ |
1726003462016073728 |