| Summary: | An individual readout of silicon photomultipliers (SiPMs) would enhance the performance of modern positron emission tomography (PET) systems. However, as it difficult to achieve in practice, a multiplexing readout of SiPM arrays could be performed instead. In this study, we characterized the performance of three PET detector modules utilizing three different SiPM models with active areas of 3 × 3, 4 × 4, and 6 × 6 mm<sup>2</sup>. Each SiPM array was coupled with a 4 × 4 LYSO crystal block. For SiPM multiplexing, we used a discretized positioning circuit to obtain position and energy information, and applied a first-order capacitive high-pass filter to enhance the time-of-flight measurement capability of the PET detector. The energy performance was similar among the three different SiPM arrays, with an energy resolution of 10%–11%. The best timing performance was achieved with the SiPM array with an active area of 6 × 6 mm<sup>2</sup>, which yielded a coincidence timing resolution (CTR) value of 401 ps FWHM when an analog high-pass filter was applied. We expect that, in combination with high-performance SiPM multiplexing techniques, the SiPM array with an active area of 6 × 6 mm<sup>2</sup> can provide a cost-effective solution for developing a whole-body PET scanner.
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