Evaluation of Biomarkers of NAFLD in a Cohort of Morbidly Obese Patients
Hepatocyte apoptosis is a key event in nonalcoholic fatty liver disease (NAFLD), and serum apoptotic markers are emerging as surrogate markers for NAFLD. We studied the role of caspase-cleaved cytokeratin18 in the diagnosis of fibrosis in a cohort of 127 morbidly obese patients and also performed a...
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doaj-6491a7ac77164446a7991b6fed5f6e292020-11-24T23:22:24ZengHindawi LimitedJournal of Nutrition and Metabolism2090-07242090-07322011-01-01201110.1155/2011/369168369168Evaluation of Biomarkers of NAFLD in a Cohort of Morbidly Obese PatientsJulia Kälsch0Lars P. Bechmann1Hagen Kälsch2Martin Schlattjan3Jochen Erhard4Guido Gerken5Ali Canbay6Division of Gastroenterology and Hepatology, University Hospital Essen, 45122 Essen, GermanyDivision of Gastroenterology and Hepatology, University Hospital Essen, 45122 Essen, GermanyDivision of Cardiology, University Hospital Essen, 45122 Essen, GermanyDivision of Gastroenterology and Hepatology, University Hospital Essen, 45122 Essen, GermanyDepartment of Surgery, Evangelisches Krankenhaus Dinslaken, 46535 Dinslaken, GermanyDivision of Gastroenterology and Hepatology, University Hospital Essen, 45122 Essen, GermanyDivision of Gastroenterology and Hepatology, University Hospital Essen, 45122 Essen, GermanyHepatocyte apoptosis is a key event in nonalcoholic fatty liver disease (NAFLD), and serum apoptotic markers are emerging as surrogate markers for NAFLD. We studied the role of caspase-cleaved cytokeratin18 in the diagnosis of fibrosis in a cohort of 127 morbidly obese patients and also performed a review of the literature biomarkers of NAFLD and fibrosis. Here, we found that cleaved caspase 18 correlated with liver steatosis and liver injury as assessed by serum transaminase levels. Furthermore, hepatocyte apoptosis as assessed by cleaved CK18 and TUNEL staining correlated with the extent of fibrosis as assessed by Sirius Red staining and serum hyaluronic acid. These results underscore the important role of hepatocyte apoptosis in the pathogenesis of fibrosis in NAFLD, which led to the utilization of surrogate markers for apoptosis in the noninvasive diagnosis of NAFLD. We furthermore reviewed current literature of biomarkers of NAFLD and fibrosis.http://dx.doi.org/10.1155/2011/369168 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Julia Kälsch Lars P. Bechmann Hagen Kälsch Martin Schlattjan Jochen Erhard Guido Gerken Ali Canbay |
spellingShingle |
Julia Kälsch Lars P. Bechmann Hagen Kälsch Martin Schlattjan Jochen Erhard Guido Gerken Ali Canbay Evaluation of Biomarkers of NAFLD in a Cohort of Morbidly Obese Patients Journal of Nutrition and Metabolism |
author_facet |
Julia Kälsch Lars P. Bechmann Hagen Kälsch Martin Schlattjan Jochen Erhard Guido Gerken Ali Canbay |
author_sort |
Julia Kälsch |
title |
Evaluation of Biomarkers of NAFLD in a Cohort of Morbidly Obese Patients |
title_short |
Evaluation of Biomarkers of NAFLD in a Cohort of Morbidly Obese Patients |
title_full |
Evaluation of Biomarkers of NAFLD in a Cohort of Morbidly Obese Patients |
title_fullStr |
Evaluation of Biomarkers of NAFLD in a Cohort of Morbidly Obese Patients |
title_full_unstemmed |
Evaluation of Biomarkers of NAFLD in a Cohort of Morbidly Obese Patients |
title_sort |
evaluation of biomarkers of nafld in a cohort of morbidly obese patients |
publisher |
Hindawi Limited |
series |
Journal of Nutrition and Metabolism |
issn |
2090-0724 2090-0732 |
publishDate |
2011-01-01 |
description |
Hepatocyte apoptosis is a key event in nonalcoholic fatty liver disease (NAFLD), and serum apoptotic markers are emerging as surrogate markers for NAFLD. We studied the role of caspase-cleaved cytokeratin18 in the diagnosis of fibrosis in a cohort of 127 morbidly obese patients and also performed a review of the literature biomarkers of NAFLD and fibrosis. Here, we found that cleaved caspase 18 correlated with liver steatosis and liver injury as assessed by serum transaminase levels. Furthermore, hepatocyte apoptosis as assessed by cleaved CK18 and TUNEL staining correlated with the extent of fibrosis as assessed by Sirius Red staining and serum hyaluronic acid. These results underscore the important role of hepatocyte apoptosis in the pathogenesis of fibrosis in NAFLD, which led to the utilization of surrogate markers for apoptosis in the noninvasive diagnosis of NAFLD. We furthermore reviewed current literature of biomarkers of NAFLD and fibrosis. |
url |
http://dx.doi.org/10.1155/2011/369168 |
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