The cross-hemispheric nigrostriatal pathway prevents the expression of levodopa-induced dyskinesias

The cross-hemispheric nigrostriatal pathway prevents the expression of levodopa-induced dyskinesias

Parkinson's disease (PD) is a neurodegenerative movement disorder that is routinely treated with levodopa. Unfortunately, long-term dopamine replacement therapy using levodopa leads to levodopa-induced dyskinesias (LID), a significant and disabling side-effect. Clinical findings indicate that L...

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Bibliographic Details
Main Authors: Vishakh Iyer, Kala Venkiteswaran, Sandip Savaliya, Christopher A. Lieu, Erin Handly, Timothy P. Gilmour, Allen R. Kunselman, Thyagarajan Subramanian
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Neurobiology of Disease
Subjects:
Dyskinesia
Dopamine
Levodopa
Parkinson's disease
Interhemispheric
Rat
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996121002400

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