Strategies for the Development of Conotoxins as New Therapeutic Leads
Peptide toxins typically bind to their target ion channels or receptors with high potency and selectivity, making them attractive leads for therapeutic development. In some cases the native peptide as it is found in the venom from which it originates can be used directly, but in many instances it is...
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MDPI AG
2013-06-01
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| Series: | Marine Drugs |
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| Online Access: | http://www.mdpi.com/1660-3397/11/7/2293 |
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doaj-649b36f659cf4c7e9eaca10aa37cbfc82020-11-24T22:38:54ZengMDPI AGMarine Drugs1660-33972013-06-011172293231310.3390/md11072293Strategies for the Development of Conotoxins as New Therapeutic LeadsJonathan B. BaellRyan M. BradyRaymond S. NortonPeptide toxins typically bind to their target ion channels or receptors with high potency and selectivity, making them attractive leads for therapeutic development. In some cases the native peptide as it is found in the venom from which it originates can be used directly, but in many instances it is desirable to truncate and/or stabilize the peptide to improve its therapeutic properties. A complementary strategy is to display the key residues that make up the pharmacophore of the peptide toxin on a non-peptidic scaffold, thereby creating a peptidomimetic. This review exemplifies these approaches with peptide toxins from marine organisms, with a particular focus on conotoxins.http://www.mdpi.com/1660-3397/11/7/2293peptide toxinpeptidomimeticion channelpaincone snail |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Jonathan B. Baell Ryan M. Brady Raymond S. Norton |
| spellingShingle |
Jonathan B. Baell Ryan M. Brady Raymond S. Norton Strategies for the Development of Conotoxins as New Therapeutic Leads Marine Drugs peptide toxin peptidomimetic ion channel pain cone snail |
| author_facet |
Jonathan B. Baell Ryan M. Brady Raymond S. Norton |
| author_sort |
Jonathan B. Baell |
| title |
Strategies for the Development of Conotoxins as New Therapeutic Leads |
| title_short |
Strategies for the Development of Conotoxins as New Therapeutic Leads |
| title_full |
Strategies for the Development of Conotoxins as New Therapeutic Leads |
| title_fullStr |
Strategies for the Development of Conotoxins as New Therapeutic Leads |
| title_full_unstemmed |
Strategies for the Development of Conotoxins as New Therapeutic Leads |
| title_sort |
strategies for the development of conotoxins as new therapeutic leads |
| publisher |
MDPI AG |
| series |
Marine Drugs |
| issn |
1660-3397 |
| publishDate |
2013-06-01 |
| description |
Peptide toxins typically bind to their target ion channels or receptors with high potency and selectivity, making them attractive leads for therapeutic development. In some cases the native peptide as it is found in the venom from which it originates can be used directly, but in many instances it is desirable to truncate and/or stabilize the peptide to improve its therapeutic properties. A complementary strategy is to display the key residues that make up the pharmacophore of the peptide toxin on a non-peptidic scaffold, thereby creating a peptidomimetic. This review exemplifies these approaches with peptide toxins from marine organisms, with a particular focus on conotoxins. |
| topic |
peptide toxin peptidomimetic ion channel pain cone snail |
| url |
http://www.mdpi.com/1660-3397/11/7/2293 |
| work_keys_str_mv |
AT jonathanbbaell strategiesforthedevelopmentofconotoxinsasnewtherapeuticleads AT ryanmbrady strategiesforthedevelopmentofconotoxinsasnewtherapeuticleads AT raymondsnorton strategiesforthedevelopmentofconotoxinsasnewtherapeuticleads |
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1725711237643239424 |