Orf virus 002 protein targets ovine protein S100A4 and inhibits NF-kappa B signaling

Orf virus 002 protein targets ovine protein S100A4 and inhibits NF-kappa B signaling

Orf virus (ORFV), a member of Parapoxvirus, has evolved various strategies to modulate the immune responses of host cells. The ORFV-encoded protein ORFV002, a regulator factor, has been found to inhibit the acetylation of NF-κB-p65 by blocking phosphorylation of NF-kB-p65 at Ser276 and also to disru...

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Bibliographic Details
Main Authors: Daxiang Chen, Zewei Zheng, Bin Xiao, Wei Li, Mingjian Long, Huiqin Chen, Ming Li, Daniel L Rock, Wenbo Hao, Shuhong Luo
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-09-01
Series:Frontiers in Microbiology
Subjects:
inhibition
Interaction
NF-κB
yeast two-hybrid
S100A4
ORFV002
Online Access:http://journal.frontiersin.org/Journal/10.3389/fmicb.2016.01389/full

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