Kawasaki Disease and Vaccination: Prospective Case-Control and Case-Crossover Studies among Infants in Japan
The causal effects of vaccines on Kawasaki disease (KD) remain elusive. We aimed to examine the association between vaccines administered during infancy and the development of KD in Japan. We conducted a multicenter prospective case-control study using questionnaires and compared the vaccination sta...
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doaj-64a6826b404645328b7b00a47401370a2021-08-26T14:25:40ZengMDPI AGVaccines2076-393X2021-07-01983983910.3390/vaccines9080839Kawasaki Disease and Vaccination: Prospective Case-Control and Case-Crossover Studies among Infants in JapanKenji Murata0Sagano Onoyama1Kenichiro Yamamura2Yumi Mizuno3Kenji Furuno4Keita Matsubara5Ken Hatae6Kiminori Masuda7Yuichi Nomura8Takuro Ohno9Akiko Kinumaki10Masaru Miura11Yasunari Sakai12Shouichi Ohga13Wakaba Fukushima14Junji Kishimoto15Yosikazu Nakamura16Toshiro Hara17Kawasaki Disease Center, Fukuoka Children’s Hospital, Fukuoka 813–0017, JapanKawasaki Disease Center, Fukuoka Children’s Hospital, Fukuoka 813–0017, JapanDepartment of Perinatal and Pediatric Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812–8582, JapanKawasaki Disease Center, Fukuoka Children’s Hospital, Fukuoka 813–0017, JapanKawasaki Disease Center, Fukuoka Children’s Hospital, Fukuoka 813–0017, JapanDepartment of Pediatrics, Hiroshima City Funairi Citizens Hospital, Hiroshima 730–0844, JapanDepartment of Pediatrics, Japanese Red Cross Fukuoka Hospital, Fukuoka 815–8555, JapanDepartment of Pediatrics, Kagoshima City Hospital, Kagoshima 890–8760, JapanDepartment of Pediatrics, Kagoshima City Hospital, Kagoshima 890–8760, JapanDepartment of Pediatrics, Oita Prefectural Hospital, Oita 870–8511, JapanDepartment of General Pediatrics, Tokyo Metropolitan Children’s Medical Center, Fuchu, Tokyo 183–8561, JapanDepartment of Cardiology, Tokyo Metropolitan Children’s Medical Center, Fuchu, Tokyo 183–8561, JapanDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812–8582, JapanDepartment of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812–8582, JapanDepartment of Public Health, Research Center for Infectious Disease Sciences, Osaka City University Graduate School of Medicine, Osaka City University, Osaka 558–8585, JapanCenter for Clinical and Translational Research, Kyushu University Hospital, Fukuoka 812–8582, JapanDepartment of Public Health, Jichi Medical University, Shimotsuke 329–0498, JapanKawasaki Disease Center, Fukuoka Children’s Hospital, Fukuoka 813–0017, JapanThe causal effects of vaccines on Kawasaki disease (KD) remain elusive. We aimed to examine the association between vaccines administered during infancy and the development of KD in Japan. We conducted a multicenter prospective case-control study using questionnaires and compared the vaccination status of infants (age: 6 weeks to 9 months) who developed KD (KD group; <i>n</i> = 102) and those who did not develop KD (non-KD group; <i>n</i> = 139). Next, we performed a case-crossover study of 98 cases in the KD group and compared the status of vaccinations between the case and control periods. We also compared the incidence of KD in children for each 5-year period before and after the addition of new vaccines (2012–2013) using data from the Nationwide Survey of KD. In the case-control study, the vaccination status of the KD and control groups did not differ to a statistically significant extent. Multivariable analysis of the vaccination status and patient backgrounds showed no significant association between vaccination and KD development. In the case-crossover study, the status of vaccinations during the case and control periods did not differ to a statistically significant extent. In the analysis of data from the Nationwide Survey of KD, the incidence of KD in children of ages subject to frequent vaccination showed no significant increases in the latter five years, 2014–2018. Based on these prospective analyses, we confirmed that vaccination in early infancy did not affect the risk of KD.https://www.mdpi.com/2076-393X/9/8/839Kawasaki diseasevaccinesinfantcase-control studycase-crossover studyNationwide Survey of Kawasaki disease in Japan |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kenji Murata Sagano Onoyama Kenichiro Yamamura Yumi Mizuno Kenji Furuno Keita Matsubara Ken Hatae Kiminori Masuda Yuichi Nomura Takuro Ohno Akiko Kinumaki Masaru Miura Yasunari Sakai Shouichi Ohga Wakaba Fukushima Junji Kishimoto Yosikazu Nakamura Toshiro Hara |
spellingShingle |
Kenji Murata Sagano Onoyama Kenichiro Yamamura Yumi Mizuno Kenji Furuno Keita Matsubara Ken Hatae Kiminori Masuda Yuichi Nomura Takuro Ohno Akiko Kinumaki Masaru Miura Yasunari Sakai Shouichi Ohga Wakaba Fukushima Junji Kishimoto Yosikazu Nakamura Toshiro Hara Kawasaki Disease and Vaccination: Prospective Case-Control and Case-Crossover Studies among Infants in Japan Vaccines Kawasaki disease vaccines infant case-control study case-crossover study Nationwide Survey of Kawasaki disease in Japan |
author_facet |
Kenji Murata Sagano Onoyama Kenichiro Yamamura Yumi Mizuno Kenji Furuno Keita Matsubara Ken Hatae Kiminori Masuda Yuichi Nomura Takuro Ohno Akiko Kinumaki Masaru Miura Yasunari Sakai Shouichi Ohga Wakaba Fukushima Junji Kishimoto Yosikazu Nakamura Toshiro Hara |
author_sort |
Kenji Murata |
title |
Kawasaki Disease and Vaccination: Prospective Case-Control and Case-Crossover Studies among Infants in Japan |
title_short |
Kawasaki Disease and Vaccination: Prospective Case-Control and Case-Crossover Studies among Infants in Japan |
title_full |
Kawasaki Disease and Vaccination: Prospective Case-Control and Case-Crossover Studies among Infants in Japan |
title_fullStr |
Kawasaki Disease and Vaccination: Prospective Case-Control and Case-Crossover Studies among Infants in Japan |
title_full_unstemmed |
Kawasaki Disease and Vaccination: Prospective Case-Control and Case-Crossover Studies among Infants in Japan |
title_sort |
kawasaki disease and vaccination: prospective case-control and case-crossover studies among infants in japan |
publisher |
MDPI AG |
series |
Vaccines |
issn |
2076-393X |
publishDate |
2021-07-01 |
description |
The causal effects of vaccines on Kawasaki disease (KD) remain elusive. We aimed to examine the association between vaccines administered during infancy and the development of KD in Japan. We conducted a multicenter prospective case-control study using questionnaires and compared the vaccination status of infants (age: 6 weeks to 9 months) who developed KD (KD group; <i>n</i> = 102) and those who did not develop KD (non-KD group; <i>n</i> = 139). Next, we performed a case-crossover study of 98 cases in the KD group and compared the status of vaccinations between the case and control periods. We also compared the incidence of KD in children for each 5-year period before and after the addition of new vaccines (2012–2013) using data from the Nationwide Survey of KD. In the case-control study, the vaccination status of the KD and control groups did not differ to a statistically significant extent. Multivariable analysis of the vaccination status and patient backgrounds showed no significant association between vaccination and KD development. In the case-crossover study, the status of vaccinations during the case and control periods did not differ to a statistically significant extent. In the analysis of data from the Nationwide Survey of KD, the incidence of KD in children of ages subject to frequent vaccination showed no significant increases in the latter five years, 2014–2018. Based on these prospective analyses, we confirmed that vaccination in early infancy did not affect the risk of KD. |
topic |
Kawasaki disease vaccines infant case-control study case-crossover study Nationwide Survey of Kawasaki disease in Japan |
url |
https://www.mdpi.com/2076-393X/9/8/839 |
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