The Bed Nucleus of the Stria Terminalis as a Brain Correlate of Psychological Inflexibility in Fibromyalgia
This study explored the brain structural correlates of psychological flexibility (PF) as measured with the Psychological Inflexibility in Pain Scale (PIPS) in patients with fibromyalgia (FM). Structural magnetic resonance imaging data from 47 FM patients were used to identify Gray Matter Volume (GMV...
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doaj-64a9bc3c3ebc40af950292f491e687d82020-11-25T01:12:28ZengMDPI AGJournal of Clinical Medicine2077-03832020-01-019237410.3390/jcm9020374jcm9020374The Bed Nucleus of the Stria Terminalis as a Brain Correlate of Psychological Inflexibility in FibromyalgiaAlbert Feliu-Soler0Ignacio Martínez-Zalacaín1Adrián Pérez-Aranda2Xavier Borràs3Laura Andrés-Rodríguez4Juan P. Sanabria-Mazo5Nicolás Fayed6Christian Stephan-Otto7Christian Núñez8Carles Soriano-Mas9Juan V. Luciano10Institut de Recerca Sant Joan de Déu, 08950 Esplugues de Llobregat, SpainDepartment of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, 08907 Barcelona, SpainInstitut de Recerca Sant Joan de Déu, 08950 Esplugues de Llobregat, SpainFaculty of Psychology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Cerdanyola del Vallès), Barcelona, SpainInstitut de Recerca Sant Joan de Déu, 08950 Esplugues de Llobregat, SpainFaculty of Psychology, Universitat Autònoma de Barcelona, 08193 Bellaterra (Cerdanyola del Vallès), Barcelona, SpainDepartment of Radiology, Quirónsalud Hospital, 50012 Zaragoza, SpainInstitut de Recerca Sant Joan de Déu, 08950 Esplugues de Llobregat, SpainInstitut de Recerca Sant Joan de Déu, 08950 Esplugues de Llobregat, SpainDepartment of Psychiatry, Bellvitge University Hospital, Bellvitge Biomedical Research Institute-IDIBELL, 08907 Barcelona, SpainInstitut de Recerca Sant Joan de Déu, 08950 Esplugues de Llobregat, SpainThis study explored the brain structural correlates of psychological flexibility (PF) as measured with the Psychological Inflexibility in Pain Scale (PIPS) in patients with fibromyalgia (FM). Structural magnetic resonance imaging data from 47 FM patients were used to identify Gray Matter Volume (GMV) alterations related to PIPS scores. Brain GMV clusters related to PIPS were then correlated with clinical and cognitive variables to further explore how emerged brain clusters were intertwined with FM symptomatology. Longitudinal changes in PIPS-related brain clusters values were assessed by studying pre−post data from 30 patients (15 allocated to a mindfulness-based stress reduction (MBSR) program and 15 to treatment-as-usual). Changes in PIPS-related brain clusters were also explored in participants showing greater/lower longitudinal changes in PIPS scores. PIPS scores were positively associated with GMV in a bilateral cluster in the ventral part of the bed nucleus of the stria terminalis (BNST). Significant associations between BNST cluster with functional impairment, depressive symptomatology, perceived stress and the nonjudging mindfulness facet were observed. Participants reporting greater pre−post increases in PIPS scores showed greater increases in BNST cluster values. These findings contribute to the understanding on the neurobiological bases of PF in FM and encourage further explorations of the role of the BNST in chronic pain.https://www.mdpi.com/2077-0383/9/2/374fibromyalgiapsychological inflexibilitymindfulnessbed nucleus of the stria terminalisneuroimaging |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Albert Feliu-Soler Ignacio Martínez-Zalacaín Adrián Pérez-Aranda Xavier Borràs Laura Andrés-Rodríguez Juan P. Sanabria-Mazo Nicolás Fayed Christian Stephan-Otto Christian Núñez Carles Soriano-Mas Juan V. Luciano |
spellingShingle |
Albert Feliu-Soler Ignacio Martínez-Zalacaín Adrián Pérez-Aranda Xavier Borràs Laura Andrés-Rodríguez Juan P. Sanabria-Mazo Nicolás Fayed Christian Stephan-Otto Christian Núñez Carles Soriano-Mas Juan V. Luciano The Bed Nucleus of the Stria Terminalis as a Brain Correlate of Psychological Inflexibility in Fibromyalgia Journal of Clinical Medicine fibromyalgia psychological inflexibility mindfulness bed nucleus of the stria terminalis neuroimaging |
author_facet |
Albert Feliu-Soler Ignacio Martínez-Zalacaín Adrián Pérez-Aranda Xavier Borràs Laura Andrés-Rodríguez Juan P. Sanabria-Mazo Nicolás Fayed Christian Stephan-Otto Christian Núñez Carles Soriano-Mas Juan V. Luciano |
author_sort |
Albert Feliu-Soler |
title |
The Bed Nucleus of the Stria Terminalis as a Brain Correlate of Psychological Inflexibility in Fibromyalgia |
title_short |
The Bed Nucleus of the Stria Terminalis as a Brain Correlate of Psychological Inflexibility in Fibromyalgia |
title_full |
The Bed Nucleus of the Stria Terminalis as a Brain Correlate of Psychological Inflexibility in Fibromyalgia |
title_fullStr |
The Bed Nucleus of the Stria Terminalis as a Brain Correlate of Psychological Inflexibility in Fibromyalgia |
title_full_unstemmed |
The Bed Nucleus of the Stria Terminalis as a Brain Correlate of Psychological Inflexibility in Fibromyalgia |
title_sort |
bed nucleus of the stria terminalis as a brain correlate of psychological inflexibility in fibromyalgia |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2020-01-01 |
description |
This study explored the brain structural correlates of psychological flexibility (PF) as measured with the Psychological Inflexibility in Pain Scale (PIPS) in patients with fibromyalgia (FM). Structural magnetic resonance imaging data from 47 FM patients were used to identify Gray Matter Volume (GMV) alterations related to PIPS scores. Brain GMV clusters related to PIPS were then correlated with clinical and cognitive variables to further explore how emerged brain clusters were intertwined with FM symptomatology. Longitudinal changes in PIPS-related brain clusters values were assessed by studying pre−post data from 30 patients (15 allocated to a mindfulness-based stress reduction (MBSR) program and 15 to treatment-as-usual). Changes in PIPS-related brain clusters were also explored in participants showing greater/lower longitudinal changes in PIPS scores. PIPS scores were positively associated with GMV in a bilateral cluster in the ventral part of the bed nucleus of the stria terminalis (BNST). Significant associations between BNST cluster with functional impairment, depressive symptomatology, perceived stress and the nonjudging mindfulness facet were observed. Participants reporting greater pre−post increases in PIPS scores showed greater increases in BNST cluster values. These findings contribute to the understanding on the neurobiological bases of PF in FM and encourage further explorations of the role of the BNST in chronic pain. |
topic |
fibromyalgia psychological inflexibility mindfulness bed nucleus of the stria terminalis neuroimaging |
url |
https://www.mdpi.com/2077-0383/9/2/374 |
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