The Immunologic Injury Composite with Balloon Injury Leads to Dyslipidemia: A Robust Rabbit Model of Human Atherosclerosis and Vulnerable Plaque

The Immunologic Injury Composite with Balloon Injury Leads to Dyslipidemia: A Robust Rabbit Model of Human Atherosclerosis and Vulnerable Plaque

Atherosclerosis is a condition in which a lipid deposition, thrombus formation, immune cell infiltration, and a chronic inflammatory response, but its systemic study has been hampered by the lack of suitable animal models, especially in herbalism fields. We have tried to perform a perfect animal mod...

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Main Authors: Guangyin Zhang, Ming Li, Liangjun Li, Yingzhi Xu, Peng Li, Cui Yang, Yanan Zhou, Junping Zhang
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Journal of Biomedicine and Biotechnology
Online Access:http://dx.doi.org/10.1155/2012/249129
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spelling doaj-64abbd13d15f458b8e46459e922ce5d02020-11-25T02:08:39ZengHindawi LimitedJournal of Biomedicine and Biotechnology1110-72431110-72512012-01-01201210.1155/2012/249129249129The Immunologic Injury Composite with Balloon Injury Leads to Dyslipidemia: A Robust Rabbit Model of Human Atherosclerosis and Vulnerable PlaqueGuangyin Zhang0Ming Li1Liangjun Li2Yingzhi Xu3Peng Li4Cui Yang5Yanan Zhou6Junping Zhang7Office building, Rm 309, First Teaching Hospital of Tianjin University of TCM, No. 314, An Shan Xi Road, Nan Kai District, Tianjin 300193, ChinaOffice building, Rm 309, First Teaching Hospital of Tianjin University of TCM, No. 314, An Shan Xi Road, Nan Kai District, Tianjin 300193, ChinaOffice building, Rm 309, First Teaching Hospital of Tianjin University of TCM, No. 314, An Shan Xi Road, Nan Kai District, Tianjin 300193, ChinaOffice building, Rm 309, First Teaching Hospital of Tianjin University of TCM, No. 314, An Shan Xi Road, Nan Kai District, Tianjin 300193, ChinaOffice building, Rm 309, First Teaching Hospital of Tianjin University of TCM, No. 314, An Shan Xi Road, Nan Kai District, Tianjin 300193, ChinaOffice building, Rm 309, First Teaching Hospital of Tianjin University of TCM, No. 314, An Shan Xi Road, Nan Kai District, Tianjin 300193, ChinaOffice building, Rm 309, First Teaching Hospital of Tianjin University of TCM, No. 314, An Shan Xi Road, Nan Kai District, Tianjin 300193, ChinaOffice building, Rm 309, First Teaching Hospital of Tianjin University of TCM, No. 314, An Shan Xi Road, Nan Kai District, Tianjin 300193, ChinaAtherosclerosis is a condition in which a lipid deposition, thrombus formation, immune cell infiltration, and a chronic inflammatory response, but its systemic study has been hampered by the lack of suitable animal models, especially in herbalism fields. We have tried to perform a perfect animal model that completely replicates the stages of human atherosclerosis. This is the first combined study about the immunologic injury and balloon injury based on the cholesterol diet. In this study, we developed a modified protocol of the white rabbit model that could represent a novel approach to studying human atherosclerosis and vulnerable plaque.http://dx.doi.org/10.1155/2012/249129
collection DOAJ
language English
format Article
sources DOAJ
author Guangyin Zhang
Ming Li
Liangjun Li
Yingzhi Xu
Peng Li
Cui Yang
Yanan Zhou
Junping Zhang
spellingShingle Guangyin Zhang
Ming Li
Liangjun Li
Yingzhi Xu
Peng Li
Cui Yang
Yanan Zhou
Junping Zhang
The Immunologic Injury Composite with Balloon Injury Leads to Dyslipidemia: A Robust Rabbit Model of Human Atherosclerosis and Vulnerable Plaque
Journal of Biomedicine and Biotechnology
author_facet Guangyin Zhang
Ming Li
Liangjun Li
Yingzhi Xu
Peng Li
Cui Yang
Yanan Zhou
Junping Zhang
author_sort Guangyin Zhang
title The Immunologic Injury Composite with Balloon Injury Leads to Dyslipidemia: A Robust Rabbit Model of Human Atherosclerosis and Vulnerable Plaque
title_short The Immunologic Injury Composite with Balloon Injury Leads to Dyslipidemia: A Robust Rabbit Model of Human Atherosclerosis and Vulnerable Plaque
title_full The Immunologic Injury Composite with Balloon Injury Leads to Dyslipidemia: A Robust Rabbit Model of Human Atherosclerosis and Vulnerable Plaque
title_fullStr The Immunologic Injury Composite with Balloon Injury Leads to Dyslipidemia: A Robust Rabbit Model of Human Atherosclerosis and Vulnerable Plaque
title_full_unstemmed The Immunologic Injury Composite with Balloon Injury Leads to Dyslipidemia: A Robust Rabbit Model of Human Atherosclerosis and Vulnerable Plaque
title_sort immunologic injury composite with balloon injury leads to dyslipidemia: a robust rabbit model of human atherosclerosis and vulnerable plaque
publisher Hindawi Limited
series Journal of Biomedicine and Biotechnology
issn 1110-7243
1110-7251
publishDate 2012-01-01
description Atherosclerosis is a condition in which a lipid deposition, thrombus formation, immune cell infiltration, and a chronic inflammatory response, but its systemic study has been hampered by the lack of suitable animal models, especially in herbalism fields. We have tried to perform a perfect animal model that completely replicates the stages of human atherosclerosis. This is the first combined study about the immunologic injury and balloon injury based on the cholesterol diet. In this study, we developed a modified protocol of the white rabbit model that could represent a novel approach to studying human atherosclerosis and vulnerable plaque.
url http://dx.doi.org/10.1155/2012/249129
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